Home / VEGF / Recombinant Mouse VEGF 164 Protein

Recombinant Mouse VEGF 164 Protein

Catalog #: 493-MV
94 Citations 7 Reviews Datasheet / COA / SDS

Carrier Free

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493-MV-005/CF
493-MV-025/CF

With Carrier

Catalog # Availability Size / Price Qty
493-MV-005
493-MV-025
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Product Details
Citations (94)
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Reviews (7)
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Recombinant Mouse VEGF 164 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al. (1990) Proc. Natl. Acad. Sci. USA 87:1323. The ED50 for this effect is 0.8-4 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived mouse VEGF protein
Ala27-Arg190
Accession #
AAA40547
N-terminal Sequence
Analysis
Ala27
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
19.4 kDa (monomer)
SDS-PAGE
42 kDa, non-reducing conditions

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493-MV (with carrier)

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493-MV/CF (carrier free)

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COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

493-MV

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

493-MV/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 50 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: VEGF

Vascular endothelial growth factor (VEGF or VEGF‑A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult (1-3). It is a member of the PDGF family that is characterized by a cystine knot structure formed by eight conserved cysteine residues (4). Alternately spliced isoforms of 121, 145, 165, 183, 189, and 206 amino acids (aa) have been identified in humans, with 120, 164 and 188 aa isoforms found in mouse (2, 4). Isoforms other than VEGF120 and VEGF121 contain basic heparin-binding regions and are not freely diffusible (4). Mouse VEGF164 shares 97% aa sequence identity with corresponding regions of rat, 89% with human and porcine, 88% with bovine, and 90% with feline, equine and canine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells (4). Although affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity (3, 4). Human VEGF165 binds the semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2 (5). VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of endothelial cells (3, 4). In adults, VEGF functions mainly in wound healing and the female reproductive cycle (3). Pathologically, it is involved in tumor angiogenesis and vascular leakage (6, 7). Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (8). VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, oncostatin M and TNF-alpha (3, 4, 9).

References
  1. Breier, G. et al. (1992) Development 114:521.
  2. Shima, D.T. et al. (1996) J. Biol. Chem. 271:3877.
  3. Byrne, A.M. et al. (2005) J. Cell. Mol. Med. 9:777.
  4. Robinson, C.J. and S.E. Stringer (2001) J. Cell. Sci. 114:853.
  5. Pan, Q. et al. (2007) J. Biol. Chem. 282:24049.
  6. Weis, S.M. and D.A. Cheresh (2005) Nature 437:497.
  7. Thurston, G. (2002) J. Anat. 200:575.
  8. Carvalho, J.F. et al. (2007) J. Clin. Immunol. 27:246.
  9. Angelo, L.S. and R. Kurzrock (2007) Clin. Cancer Res. 13:2825.
Long Name
Vascular Endothelial Growth Factor
Entrez Gene IDs
7422 (Human); 22339 (Mouse); 83785 (Rat); 281572 (Bovine); 403802 (Canine); 493845 (Feline); 30682 (Zebrafish)
Alternate Names
MVCD1; VAS; vascular endothelial growth factor A; Vascular permeability factor; Vasculotropin; VEGF; VEGFA; VEGF-A; VEGFMGC70609; VPF; VPFvascular endothelial growth factor

Citations for Recombinant Mouse VEGF 164 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

94 Citations: Showing 1 - 10
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  1. Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis
    Authors: Chaube, B;Citrin, KM;Sahraei, M;Singh, AK;de Urturi, DS;Ding, W;Pierce, RW;Raaisa, R;Cardone, R;Kibbey, R;Fernández-Hernando, C;Suárez, Y;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis
    Authors: Han, Y;Tomita, T;Kato, M;Ashihara, N;Higuchi, Y;Matoba, H;Wang, W;Hayashi, H;Itoh, Y;Takahashi, S;Kurita, H;Nakayama, J;Okumura, N;Hiratsuka, S;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  3. Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
    Authors: Alber, AB;Marquez, HA;Ma, L;Kwong, G;Thapa, BR;Villacorta-Martin, C;Lindstrom-Vautrin, J;Bawa, P;Wang, F;Luo, Y;Ikonomou, L;Shi, W;Kotton, DN;
    Nature communications
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes
    Authors: Lee, HJ;Lee, J;Yang, MJ;Kim, YC;Hong, SP;Kim, JM;Hwang, GS;Koh, GY;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Mice with endothelial cell-selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction
    Authors: V Buncha, KA Fopiano, L Lang, C Williams, A Horuzsko, JA Filosa, G Kapuku, Z Bagi
    Physiological Reports, 2023-03-01;11(6):e15643.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Targeting Vascular Endothelial Growth Factor Receptors as a Therapeutic Strategy for Osteoarthritis and Associated Pain
    Authors: K Ma, G Singh, J Wang, I O-Sullivan, G Votta-Veli, B Bruce, AN Anbazhagan, AJ van Wijnen, HJ Im
    International journal of biological sciences, 2023-01-01;19(2):675-690.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  7. Assessment of mouse VEGF neutralization by ranibizumab and aflibercept
    Authors: Y Ichiyama, R Matsumoto, S Obata, O Sawada, Y Saishin, M Kakinoki, T Sawada, M Ohji
    PLoS ONE, 2022-12-21;17(12):e0278951.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Western Blot
  8. Ras drives malignancy through stem cell crosstalk with the microenvironment
    Authors: S Yuan, KS Stewart, Y Yang, MD Abdusselam, SM Parigi, TY Feinberg, K Tumaneng, H Yang, JM Levorse, L Polak, D Ng, E Fuchs
    Nature, 2022-11-30;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  9. Neuroimmune Responses in a New Experimental Animal Model of Cerebral Aspergillosis
    Authors: BN Sullivan, MA Baggett, C Guillory, M Jones, C Steele
    MBio, 2022-08-30;0(0):e0225422.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  10. Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production
    Authors: D Pan, W Wu, G Zuo, X Xie, H Li, X Ren, C Kong, W Zhou, Z Zhang, M Waterfall, S Chen
    Cellular Signalling, 2022-07-26;98(0):110419.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Protective role of VEGF/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions
    Authors: CY Tsai, JCC Wu, CJ Wu, SHH Chan
    Oncogene, 2022-07-03;29(1):47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Exposure to the Dioxin-like Pollutant PCB 126 Afflicts Coronary Endothelial Cells via Increasing 4-Hydroxy-2 Nonenal: A Role for Aldehyde Dehydrogenase 2
    Authors: B Roy, Z Yang, G Pan, K Roth, M Agarwal, R Sharma, MC Petriello, SS Palaniyand
    Oncogene, 2022-06-16;10(6):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Gatekeeping role of Nf2/Merlin in vascular tip EC induction through suppression of VEGFR2 internalization
    Authors: JH Bae, MJ Yang, SH Jeong, J Kim, SP Hong, JW Kim, YH Kim, GY Koh
    Science Advances, 2022-06-10;8(23):eabn2611.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  14. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
    Authors: O Meçe, D Houbaert, ML Sassano, T Durré, H Maes, M Schaaf, S More, M Ganne, M García-Cab, M Borri, J Verhoeven, M Agrawal, K Jacobs, G Bergers, S Blacher, B Ghesquière, M Dewerchin, JV Swinnen, S Vinckier, MS Soengas, P Carmeliet, A Noël, P Agostinis
    Nature Communications, 2022-05-19;13(1):2760.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  15. Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment
    Authors: R Yang, T Pei, R Huang, Y Xiao, J Yan, J Zhu, C Zheng, W Xiao, C Huang
    Frontiers in Pharmacology, 2022-04-14;13(0):774440.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Regenerating glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy
    Authors: J Fu, T Shinjo, Q Li, R St-Louis, K Park, MG Yu, H Yokomizo, F Simao, Q Huang, IH Wu, GL King
    JCI Insight, 2022-03-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Ultraefficient extracellular vesicle-guided direct reprogramming of fibroblasts into functional cardiomyocytes
    Authors: H Kim, BW Song, SJ Park, SW Choi, H Moon, KC Hwang, SW Kang, SH Moon, Y Yang, IC Kwon, SH Kim
    Science Advances, 2022-02-25;8(8):eabj6621.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration
    Authors: A Yaguchi, M Oshikawa, G Watanabe, H Hiramatsu, N Uchida, C Hara, N Kaneko, K Sawamoto, T Muraoka, I Ajioka
    Nature Communications, 2021-11-19;12(1):6623.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage
    Authors: K Bubb, T Holzer, JL Nolte, M Krüger, R Wilson, U Schlötzer-, J Brinckmann, J Altmüller, A Aszodi, L Fleischhau, H Clausen-Sc, K Probst, B Brachvogel
    The Journal of Biological Chemistry, 2021-09-22;0(0):101224.
    Species: Mouse
    Sample Types: Recombinant Protein
    Applications: Western Blot Control
  20. Mucopolysaccharide polysulfate promotes microvascular stabilization and barrier integrity of dermal microvascular endothelial cells via activation of the angiopoietin-1/Tie2 pathway
    Authors: S Fujiwara-S, Y Ueda, M Fujikawa, M Osaki, N Yamanaka, T Matsumoto
    Journal of dermatological science, 2021-06-02;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  21. The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization
    Authors: W Li, Y Wang, L Zhu, S Du, J Mao, Y Wang, S Wang, Q Bo, Y Tu, Q Yi
    Journal of Cellular and Molecular Medicine, 2021-05-31;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  22. Activated FGF2 signaling pathway in tumor vasculature is essential for acquired resistance to anti-VEGF therapy
    Authors: K Ichikawa, S Watanabe M, Y Minoshima, J Matsui, Y Funahashi
    Sci Rep, 2020-02-19;10(1):2939.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IP
  23. A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3gamma phosphorylation
    Authors: J Yang, A Moraga, J Xu, Y Zhao, P Luo, KH Lao, A Margariti, Q Zhao, W Ding, G Wang, M Zhang, L Zheng, Z Zhang, Y Hu, W Wang, L Shen, A Smith, AM Shah, Q Wang, L Zeng
    Stem Cells, 2020-01-29;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  24. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
    Authors: E Harde, L Nicholson, B Furones Cu, D Bissen, S Wigge, S Urban, M Segarra, C Ruiz de Al, A Acker-Palm
    Elife, 2019-12-23;8(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by modulating antiangiogenic and proapoptotic pathways in vitro and in vivo
    Authors: J Li, F Tang, R Li, Z Chen, SM Lee, C Fu, J Zhang, GP Leung
    J. Nutr. Biochem., 2019-11-09;77(0):108268.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  26. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
    Authors: S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet
    Nature, 2019-10-23;574(7779):553-558.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  27. TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
    Authors: P Zizza, R Dinami, M Porru, C Cingolani, E Salvati, A Rizzo, C D'Angelo, E Petti, CA Amoreo, M Mottolese, I Sperduti, A Chambery, R Russo, P Ostano, G Chiorino, G Blandino, A Sacconi, J Cherfils-V, C Leonetti, E Gilson, A Biroccio
    Nucleic Acids Res., 2019-04-23;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  28. Age-related oxidative stress confines damage-responsive Bmi1+ cells to perivascular regions in the murine adult heart
    Authors: D Herrero, S Cañón, G Albericio, RM Carmona, S Aguilar, S Mañes, A Bernad
    Redox Biol, 2019-03-04;22(0):101156.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity
    Authors: T Ikeuchi, S de Vega, P Forcinito, AD Doyle, J Amaral, IR Rodriguez, E Arikawa-Hi, Y Yamada
    Sci Rep, 2018-12-05;8(1):17654.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling
    Authors: M Verma, Y Asakura, BSR Murakonda, T Pengo, C Latroche, B Chazaud, LK McLoon, A Asakura
    Cell Stem Cell, 2018-10-04;23(4):530-543.e9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  31. Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events
    Authors: N Honkura, M Richards, B Laviña, M Sáinz-Jasp, C Betsholtz, L Claesson-W
    Nat Commun, 2018-07-16;9(1):2746.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  32. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation
    Authors: G Del Monte-, M Ramialison, AAS Adam, B Wu, A Aharonov, G D'Uva, LM Bourke, ME Pitulescu, H Chen, JL de la Pomp, W Shou, RH Adams, SK Harten, E Tzahor, B Zhou, RP Harvey
    Nature, 2018-05-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  33. Glycosylation controls cooperative PECAM-VEGFR2-?3 integrin functions at the endothelial surface for tumor angiogenesis
    Authors: R Imamaki, K Ogawa, Y Kizuka, Y Komi, S Kojima, N Kotani, K Honke, T Honda, N Taniguchi, S Kitazume
    Oncogene, 2018-05-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models
    Authors: Y Li, JA Hickson, DJ Ambrosi, DL Haasch, KD Foster-Duk, LJ Eaton, EL Digiammari, SC Panchal, F Jiang, SR Mudd, C Zhang, SS Akella, W Gao, SL Ralston, L Naumovski, J Gu, SE Morgan-Lap
    Mol. Cancer Ther., 2018-03-28;0(0):.
    Applications: ELISA (Standard)
  35. Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis
    Authors: T Kobori, S Hamasaki, A Kitaura, Y Yamazaki, T Nishinaka, A Niwa, S Nakao, H Wake, S Mori, T Yoshino, M Nishibori, H Takahashi
    Front Immunol, 2018-03-06;9(0):334.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease
    Authors: JM Gu, S Yuan, D Sim, K Abe, P Liu, M Rosenbruch, P Bringmann, K Kauser
    Exp. Hematol., 2018-01-11;0(0):.
    Species: Mouse
    Sample Types: Recombinant Protein
    Applications: ELISA (Capture)
  37. Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons
    Authors: S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase
    Proc. Natl. Acad. Sci. U.S.A, 2017-03-07;114(12):E2486-E2493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
    Nat Commun, 2016-12-14;7(0):13885.
    Species: Human, Mouse
    Sample Types: Protein, Whole Cells
    Applications: Binding Assay, Bioassay, Immunoprecipitation
  39. A 3D Poly(ethylene glycol)-based Tumor Angiogenesis Model to Study the Influence of Vascular Cells on Lung Tumor Cell Behavior
    Sci Rep, 2016-09-06;6(0):32726.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction
    Authors: Jong-Ho Kim
    PLoS ONE, 2016-06-23;11(6):e0158067.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes
    J Immunol, 2016-05-18;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  42. Interleukin-6 Stimulates Defective Angiogenesis.
    Authors: Gopinathan G, Milagre C, Pearce O, Reynolds L, Hodivala-Dilke K, Leinster D, Zhong H, Hollingsworth R, Thompson R, Whiteford J, Balkwill F
    Cancer Res, 2015-06-16;75(15):3098-107.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  43. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.
    Authors: Wang S, Amato K, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders D, Chen J
    Mol Cell Biol, 2015-01-12;35(7):1299-313.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay
  44. Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity.
    Authors: Fleetwood F, Klint S, Hanze M, Gunneriusson E, Frejd F, Stahl S, Lofblom J
    Sci Rep, 2014-12-17;4(0):7518.
    Species: Mouse
    Sample Types: Recombinant Protein
    Applications: Bioassay
  45. Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8.
    Authors: Ding X, Lucas T, Marcuzzi G, Pfister H, Eming S
    Cancer Res, 2014-11-20;75(2):330-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment.
    Authors: Chen H, Wang S, Zhang J, Ren X, Zhang R, Shi W, Lv Y, Zhou Y, Yan X, Chen L, He L, Zhang B, Nan X, Yue W, Li Y, Pei X
    Sci Rep, 2014-08-28;4(0):6222.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Circulating mouse Flk1+/c-Kit+/CD45- cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts.
    Authors: Russell J, Brown J
    Mol Cancer, 2014-07-22;13(0):177.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. RAS interaction with PI3K p110alpha is required for tumor-induced angiogenesis.
    Authors: Murillo M, Zelenay S, Nye E, Castellano E, Lassailly F, Stamp G, Downward J
    J Clin Invest, 2014-07-08;124(8):3601-11.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  49. A Snail1/Notch1 signalling axis controls embryonic vascular development.
    Authors: Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S
    Nat Commun, 2014-06-04;5(0):3998.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo.
    Authors: Sundaram, J, Keshava, S, Gopalakrishnan, R, Esmon, C T, Pendurthi, U R, Rao, L V M
    J Thromb Haemost, 2014-05-01;12(5):690-700.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  51. Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition.
    Authors: Kawano, Natsuko, Miyado, Kenji, Yoshii, Noriko, Kanai, Seiya, Saito, Hidekazu, Miyado, Mami, Inagaki, Noboru, Odawara, Yasushi, Hamatani, Toshio, Umezawa, Akihiro
    Sci Rep, 2014-04-16;4(0):4701.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  52. The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling.
    Authors: Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, Simons M
    Proc Natl Acad Sci U S A, 2014-04-02;111(15):5514-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  53. In vitro multilineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57BL/6 mice.
    Authors: Jin, Liang, Feng, Tao, Zerda, Ricardo, Chen, Ching-Ch, Riggs, Arthur D, Ku, Hsun Ter
    Stem Cells Dev, 2014-01-04;23(8):899-909.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.
    Authors: Zhang H, Nieves J, Fraser S, Isern J, Douvaras P, Papatsenko D, D'Souza S, Lemischka I, Dyer M, Baron M
    Stem Cells, 2014-01-01;32(1):191-203.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
    Authors: Hunter, K E, Palermo, C, Kester, J C, Simpson, K, Li, J-P, Tang, L H, Klimstra, D S, Vlodavsky, I, Joyce, J A
    Oncogene, 2013-05-06;33(14):1799-808.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
    Authors: Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R
    J Immunol, 2013-04-15;190(10):5329-36.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA (Control)
  57. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis.
    Authors: Zhang G, Panigrahy D, Mahakian L, Yang J, Liu J, Stephen Lee K, Wettersten H, Ulu A, Hu X, Tam S, Hwang S, Ingham E, Kieran M, Weiss R, Ferrara K, Hammock B
    Proc Natl Acad Sci U S A, 2013-04-03;110(16):6530-5.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  58. Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.
    Authors: Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A
    J Biol Chem, 2012-12-05;288(4):2118-31.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  59. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. VEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivo.
    Authors: Caires KC, de Avila JM, Cupp AS
    Endocrinology, 2011-12-06;153(2):887-900.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  61. Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
    Authors: Cook BD, Liu S, Evans T
    Blood, 2011-04-22;117(24):6489-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway.
    Authors: Lee HK, Chauhan SK, Kay E
    Blood, 2011-04-01;117(21):5762-71.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  63. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1.
    Authors: Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D'Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chedotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C
    J. Neurosci., 2010-11-10;30(45):15052-66.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  64. T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice.
    Authors: Strissel KJ, DeFuria J, Shaul ME, Bennett G, Greenberg AS, Obin MS
    Obesity (Silver Spring), 2010-01-28;18(10):1918-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.
    Authors: Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T
    J. Clin. Invest., 2009-07-13;119(8):2257-70.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  66. Production of scFv antibody fragments from a hybridoma with functional activity against human vascular endothelial growth factor.
    Authors: Irani Y, Brereton HM, Tilton RG
    Hybridoma (Larchmt), 2009-06-01;28(3):205-9.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Binding Assay
  67. Inhibition of endothelial progenitor cell differentiation by VEGI.
    Authors: Tian F, Liang PH, Li LY
    Blood, 2009-03-27;113(21):5352-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth.
    Authors: Funa NS, Kriz V, Zang G, Calounova G, Akerblom B, Mares J, Larsson E, Sun Y, Betsholtz C, Welsh M
    Cancer Res., 2009-02-17;69(5):2141-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  69. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.
    Authors: Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, Kaminker J, Ferrara N
    Cancer Cell, 2009-01-06;15(1):21-34.
    Applications: Western Blot
  70. Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.
    Authors: Ponticelli S, Marasco D, Tarallo V, Albuquerque RJ, Mitola S, Takeda A, Stassen JM, Presta M, Ambati J, Ruvo M, De Falco S
    J. Biol. Chem., 2008-10-15;283(49):34250-9.
    Species: Mouse
    Sample Types: N/A
    Applications: ELISA (Standard)
  71. Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor.
    Authors: Nyberg P, Xie L, Sugimoto H, Colorado P, Sund M, Holthaus K, Sudhakar A, Salo T, Kalluri R
    Exp. Cell Res., 2008-08-26;314(18):3292-305.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  72. Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells.
    Authors: Lin H, Shabbir A, Molnar M, Yang J, Marion S, Canty JM, Lee T
    J. Cell. Physiol., 2008-08-01;216(2):458-68.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation.
    Authors: Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T
    Biochem. Biophys. Res. Commun., 2008-07-26;374(4):683-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Regulation of scar formation by vascular endothelial growth factor.
    Authors: Wilgus TA, Ferreira AM, Oberyszyn TM, Bergdall VK, DiPietro LA
    Lab. Invest., 2008-04-21;88(6):579-90.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  75. Interaction between bevacizumab and murine VEGF-A: a reassessment.
    Authors: Yu L, Wu X, Cheng Z, Lee CV, LeCouter J, Campa C, Fuh G, Lowman H, Ferrara N
    Invest. Ophthalmol. Vis. Sci., 2008-02-01;49(2):522-7.
    Species: Mouse
    Sample Types: N/A, Pharmaceutical, Whole Cells
    Applications: Bioassay, Surface Plasmon Resonance, Western Blot
  76. Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
    Authors: Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N
    Nature, 2007-12-06;450(7171):825-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner.
    Authors: Zhang Z, Ramirez NE, Yankeelov TE, Li Z, Ford LE, Qi Y, Pozzi A, Zutter MM
    Blood, 2007-11-27;111(4):1980-8.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  78. VEGF reduces astrogliosis and preserves neuromuscular junctions in ALS transgenic mice.
    Authors: Zheng C, Skold MK, Li J, Nennesmo I, Fadeel B, Henter JI
    Biochem. Biophys. Res. Commun., 2007-10-01;363(4):989-93.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  79. Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function.
    Authors: Rossiter H, Barresi C, Ghannadan M, Gruber F, Mildner M, Fodinger D, Tschachler E
    FASEB J., 2007-07-11;21(14):3994-4004.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  80. Corneal avascularity is due to soluble VEGF receptor-1.
    Authors: Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, Albuquerque RJ, Richter E, Sakurai E, Newcomb MT, Kleinman ME, Caldwell RB, Lin Q, Ogura Y, Orecchia A, Samuelson DA, Agnew DW, St Leger J, Green WR, Mahasreshti PJ, Curiel DT, Kwan D, Marsh H, Ikeda S, Leiper LJ, Collinson JM, Bogdanovich S, Khurana TS, Shibuya M, Baldwin ME, Ferrara N, Gerber HP, De Falco S, Witta J, Baffi JZ, Raisler BJ, Ambati J
    Nature, 2006-10-18;443(7114):993-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  81. The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
    Authors: Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
    Genes Dev., 2006-09-15;20(18):2527-38.
    Applications: ELISA (Standard)
  82. Cytokine-containing gelfoam implants at a postsurgical tumor excision site to stimulate local immune reactivity.
    Authors: Young MR
    Int. J. Cancer, 2006-07-01;119(1):133-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  83. Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx.
    Authors: Hutson MR, Zhang P, Stadt HA, Sato AK, Li YX, Burch J, Creazzo TL, Kirby ML
    Dev. Biol., 2006-06-12;295(2):486-97.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro.
    Authors: Getmanova EV, Chen Y, Bloom L, Gokemeijer J, Shamah S, Warikoo V, Wang J, Ling V, Sun L
    Chem. Biol., 2006-05-01;13(5):549-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
    Authors: Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Breant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL
    Nat. Neurosci., 2006-02-05;9(3):340-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action.
    Authors: Cao R, Bjorndahl MA, Gallego MI, Chen S, Religa P, Hansen AJ, Cao Y
    Blood, 2006-01-19;107(9):3531-6.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  87. VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis.
    Authors: Del Moral PM, Sala FG, Tefft D, Shi W, Keshet E, Bellusci S, Warburton D
    Dev. Biol., 2005-12-22;290(1):177-88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.
    Authors: Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP
    Invest. Ophthalmol. Vis. Sci., 2004-02-01;45(2):368-74.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  89. Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity.
    Authors: Yi M, Sakai T, Fassler R, Ruoslahti E
    Proc. Natl. Acad. Sci. U.S.A., 2003-09-17;100(20):11435-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  90. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.
    Authors: Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, Betsholtz C
    J. Cell Biol., 2003-06-16;161(6):1163-77.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  91. Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay.
    Authors: Guedez L, Rivera AM, Salloum R, Miller ML, Diegmueller JJ, Bungay PM, Stetler-Stevenson WG
    Am. J. Pathol., 2003-05-01;162(5):1431-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  92. Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins.
    Authors: Halin C, Niesner U, Villani ME, Zardi L, Neri D
    Int. J. Cancer, 2002-11-10;102(2):109-16.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  93. Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis.
    Authors: Segura I, 2019, Serrano A, De Buitrago GG, Gonzalez MA, Abad JL, Claveria C, Gomez L, Bernad A, Martinez-A C, Riese HH
    7096, 2002-06-01;16(8):833-41.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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