Home / Wnt-3a / Recombinant Mouse Wnt-3a Protein

Recombinant Mouse Wnt-3a Protein

Catalog #: 1324-WN
194 Citations 6 Reviews Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
1324-WN-002/CF
1324-WN-010/CF
1324-WN-500/CF

With Carrier

Catalog # Availability Size / Price Qty
1324-WN-002
1324-WN-010
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Recombinant Mouse Wnt-3a Protein Bioactivity
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Product Details
Citations (194)
FAQs
Reviews (6)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse Wnt-3a Protein Summary

Product Specifications

Purity
>75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. Fischer, L. et al. (2002) J. Biol. Chem. 277:30870. The ED50 for this effect is ≤5 ng/mL. Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells.

Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line.
Optimal concentrations should be determined by each laboratory for each application.

Source
Chinese Hamster Ovary cell line, CHO-derived mouse Wnt-3a protein
Ser19-Lys352
Accession #
P27467
N-terminal Sequence
Analysis
Ser19
Predicted Molecular Mass
37 kDa
SDS-PAGE
41 kDa, reducing conditions

Product Datasheets

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1324-WN (with carrier)

Product Datasheet
COA
SDS

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1324-WN/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

1324-WN

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
Reconstitution Reconstitute at 40 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

1324-WN/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.
Reconstitution Reconstitute at 40 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse Wnt-3a Protein Bioactivity View Larger

Recombinant Mouse Wnt-3a (Catalog # 1324-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. The activity is approximately 10-fold greater than the top competitor's Wnt-3A.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Wnt-3a

Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). As intracellular beta -catenin levels rise, beta -catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes (3). Endo-IWR 1 (Catalog # 3532, # PSM1324) is a cell-permeant small molecule inhibitor of Axin turnover that suppresses Wnt signal transduction by stabilizing the beta -catenin destruction complex (4). Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues (5). Wnt-3a has two N-linked glycosylation sites (Asn 87, Asn 298), and Ser 209 is modified with palmitoleic acid (6). Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively (6, 7). Mouse Wnt-3a shares 96% amino acid (aa) identity with human Wnt-3a, and 97% with bovine and canine Wnt-3a. The rat Wnt-3a precursor shares 100% aa identity with mouse Wnt-3a aa 63-352 (8), and also shares 87% aa identity with Wnt3. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation (9-12). Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13-15).

References
  1. Willert, K. and Nusse, R. (2012) Cold Spring Harb. Perspect. Biol. 4:a007864.
  2. MacDonald, B.T. and X. He (2012) Cold Spring Harb. Perspect. Biol. 4:a007880.
  3. Korinek, V. et al. (1997) Science 275:1784.
  4. Chen, B. et al. (2009) Nat. Chem. Biol. 5:100.
  5. Smolich, B.D. et al. (1993) Mol. Biol. Cell 4:1267.
  6. Takada, R. et al. (2006) Dev. Cell 11:791.
  7. Komekado, H. (2007) Genes Cells 12:521.
  8. Entrez Accession # NP_001100475.
  9. Dunty Jr. W. C. et al. (2008) Development 135:85.
  10. Ikeya, M. and S. Takada (2001) Mech. Dev. 103:27.
  11. Lee, S. M. et al. (2000) Development 127:457.
  12. Takada, S. et al. (1994) Genes Dev. 8:174.
  13. Willert, K. et al. (2003) Nature 423:6938.
  14. Kalani, M.Y. et al. (2008) Proc. Natl. Acad. Sci. USA 105:16970.
  15. Ten Berge, D. et al. (2011) Nat. Cell Biol. 13:1070.
Long Name
Wingless-type MMTV Integration Site Family, Member 3a
Entrez Gene IDs
89780 (Human); 22416 (Mouse)
Alternate Names
MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a

Citations for Recombinant Mouse Wnt-3a Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

194 Citations: Showing 1 - 10
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  1. 5-Aza-2'-Deoxycytidine Ameliorates Choroidal Neovascularization by Inhibiting the Wnt/?-Catenin Signaling Pathway
    Authors: Wu, X;Yang, X;Dai, X;Chen, X;Shen, M;Dai, J;Yuan, F;Wang, L;Yuan, Y;Feng, Y;
    Investigative ophthalmology & visual science
    Species: Murine polyomavirus strain A3
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/?-catenin to induce exit from quiescence
    Authors: Robertson, FL;O'Duibhir, E;Gangoso, E;Bressan, RB;Bulstrode, H;Marqu�s-Torrej�n, M�;Ferguson, KM;Blin, C;Grant, V;Alfazema, N;Morrison, GM;Pollard, SM;
    Cell reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a
    Authors: Li, C;Wu, Y;Huang, MY;Song, XJ;
    Biomedicines
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. Hypercapnia alters stromal-derived Wnt production limiting beta-catenin signaling and proliferation in alveolar type 2 cells
    Authors: LA Dada, LC Welch, ND Magnani, Z Ren, H Han, PL Brazee, D Celli, AS Flozak, A Weng, MM Herrerias, V Kryvenko, I Vadász, CE Runyan, H Abdala-Val, M Shigemura, SM Casalino-M, AV Misharin, GRS Budinger, CJ Gottardi, JI Sznajder
    JCI Insight, 2023-02-22;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates
    Authors: M Nomura, Y Yokoyama, D Yoshimura, Y Minagawa, A Yamamoto, Y Tanaka, N Sekiguchi, D Marukawa, M Ichihara, H Itakura, K Matsumoto, Y Morimoto, H Tomihara, A Inoue, T Ogino, N Miyoshi, H Takahashi, H Takahashi, M Uemura, S Kobayashi, T Mizushima, T Anada, M Mori, Y Doki, M Tanaka, H Eguchi, H Yamamoto
    International Journal of Molecular Sciences, 2023-02-16;24(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation
    Authors: YF Wong, Y Kumar, M Proks, JAR Herrera, MM Rothová, RS Monteiro, S Pozzi, RE Jennings, NA Hanley, WA Bickmore, JM Brickman
    Nature Cell Biology, 2023-01-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select
    Authors: Y Niu, CA Ferreira A, X Li, E Kamali, O Haagen Nie, C Storgaard, M Frödin
    Nature Genetics, 2022-12-05;54(12):1983-1993.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  8. Cellular shape reinforces niche to stem cell signaling in the small intestine
    Authors: N Pentinmikk, R Lozano, S Scharaw, S Andersson, JI Englund, D Castillo-A, A Gallagher, M Broberg, KY Song, A Sola Carva, AT Speidel, M Sundstrom, N Allbritton, MM Stevens, OD Klein, A Teixeira, P Katajisto
    Science Advances, 2022-10-14;8(41):eabm1847.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes
    Authors: G Pizzolato, L Moparthi, S Söderholm, C Cantù, S Koch
    Journal of Cell Science, 2022-10-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  10. Antibody targeting of E3 ubiquitin ligases for receptor degradation
    Authors: H Marei, WK Tsai, YS Kee, K Ruiz, J He, C Cox, T Sun, S Penikalapa, P Dwivedi, M Choi, D Kan, P Saenz-Lope, K Dorighi, P Zhang, YT Kschonsak, N Kljavin, D Amin, I Kim, AG Mancini, T Nguyen, C Wang, E Janezic, A Doan, E Mai, H Xi, C Gu, M Heinlein, B Biehs, J Wu, I Lehoux, S Harris, L Comps-Agra, D Seshasayee, FJ de Sauvage, M Grimmer, J Li, NJ Agard, F de Sousa E
    Nature, 2022-09-21;610(7930):182-189.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  11. Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm
    Authors: Z Wang, R Fan, A Russo, FM Cernilogar, A Nuber, S Schirge, I Shcherbako, I Dzhilyanov, E Ugur, T Anton, L Richter, H Leonhardt, H Lickert, G Schotta
    Nature Communications, 2022-09-19;13(1):5447.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. R-spondin3 is a myokine that differentiates myoblasts to type I fibres
    Authors: Y Mita, H Zhu, Y Furuichi, H Hamaguchi, Y Manabe, NL Fujii
    Scientific Reports, 2022-07-29;12(1):13020.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Functionalized 3D-Printed ST2/Gelatin Methacryloyl/Polcaprolactone Scaffolds for Enhancing Bone Regeneration with Vascularization
    Authors: G Liu, J Chen, X Wang, Y Liu, Y Ma, X Tu
    International Journal of Molecular Sciences, 2022-07-28;23(15):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme
    Authors: G Jacquemin, A Wurmser, M Huyghe, W Sun, Z Homayed, C Merle, M Perkins, F Qasrawi, S Richon, F Dingli, G Arras, D Loew, D Vignjevic, J Pannequin, S Fre
    Elife, 2022-05-11;11(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  15. Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/beta-catenin signaling in obstructed kidneys in vivo
    Authors: Y Zhang, Y Wang, G Zheng, Y Liu, J Li, H Huang, C Xu, Y Zeng, X Zhang, J Qin, C Dai, HO Hambrock, U Hartmann, B Feng, KK Mak, Y Liu, HY Lan, Y Huang, ZH Zheng, Y Xia
    The Journal of Biological Chemistry, 2022-05-04;0(0):102010.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Cell Culture
  16. The Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression
    Authors: S Mancarella, G Serino, S Coletta, R Armentano, F Dituri, F Ardito, A Ruzzenente, I Fabregat, G Giannelli
    International Journal of Molecular Sciences, 2022-04-10;23(8):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. Platelet-derived growth factor-BB regenerates functional periodontal ligament in the tooth replantation
    Authors: K Komatsu, H Ideno, T Shibata, K Nakashima, A Nifuji
    Scientific Reports, 2022-02-25;12(1):3223.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Transplantation of intestinal organoids into a mouse model of colitis
    Authors: S Watanabe, S Kobayashi, N Ogasawara, R Okamoto, T Nakamura, M Watanabe, KB Jensen, S Yui
    Nature Protocols, 2022-02-02;0(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  19. Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
    Authors: CM Termini, A Pang, T Fang, M Roos, VY Chang, Y Zhang, NJ Setiawan, L Signaevska, M Li, MM Kim, O Tabibi, PK Lin, JP Sasine, A Chatterjee, R Murali, HA Himburg, JP Chute
    Nature Communications, 2021-11-30;12(1):6990.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas
    Authors: S Heino, S Fang, M Lähde, J Högström, S Nassiri, A Campbell, D Flanagan, A Raven, M Hodder, N Nasreddin, HH Xue, M Delorenzi, S Leedham, TV Petrova, O Sansom, K Alitalo
    Science Advances, 2021-11-17;7(47):eabj0512.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  21. Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
    Authors: RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander
    Nature Communications, 2021-11-17;12(1):6636.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
    Authors: C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Ise, LM Sawyer, H Benchabane, H Wang, N Bunnag, B Li, DT Wynn, F Yang, M Garcia-Con, CH Williams, S Dakshanamu, CC Hong, NG Ayad, AJ Capobianco, Y Ahmed, E Lee, DJ Robbins
    Nature Communications, 2021-09-06;12(1):5263.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells
    Authors: N Aaron, MJ Kraakman, Q Zhou, Q Liu, S Costa, J Yang, L Liu, L Yu, L Wang, Y He, L Fan, H Hirakawa, L Ding, J Lo, W Wang, B Zhao, E Guo, L Sun, CJ Rosen, L Qiang
    Elife, 2021-06-22;10(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis
    Authors: A Weinstock, K Rahman, O Yaacov, H Nishi, P Menon, CA Nikain, ML Garabedian, S Pena, N Akbar, BE Sansbury, SP Heffron, J Liu, G Marecki, D Fernandez, EJ Brown, KV Ruggles, SA Ramsey, C Giannarell, M Spite, RP Choudhury, P Loke, EA Fisher
    Elife, 2021-03-15;10(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Phosphorylation-induced changes in the PDZ domain of Dishevelled 3
    Authors: M Jurásek, J Kumar, P Paclíková, A Kumari, K Tripsianes, V Bryja, R Vácha
    Scientific Reports, 2021-01-15;11(1):1484.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. 12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling
    Authors: KA Radaszkiew, D Beckerová, L Woloszczuk, TW Radaszkiew, P Lesáková, OV Blaná?ová, L Kubala, P Humpolí?ek, J Pachernik
    Sci Rep, 2020-09-28;10(1):15922.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Wnt/&beta-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells
    Authors: DP Bagchi, A Nishii, Z Li, JB DelPropost, CA Corsa, H Mori, J Hardij, BS Learman, CN Lumeng, OA MacDougald
    Mol Metab, 2020-09-09;42(0):101078.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  28. Drug-Induced Na�ve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic &beta-Cell Lineage
    Authors: Y Kiyokawa, M Sato, H Noguchi, E Inada, Y Iwase, N Kubota, T Sawami, M Terunuma, T Maeda, H Hayasaki, I Saitoh
    Journal of Clinical Medicine, 2020-09-02;9(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In�Vivo
    Authors: Y Miao, A Ha, W de Lau, K Yuki, AJM Santos, C You, MH Geurts, J Puschhof, C Pleguezuel, WC Peng, R Senlice, C Piani, JW Buikema, OM Gbenedio, M Vallon, J Yuan, S de Haan, W Hemrika, K Rösch, LT Dang, D Baker, M Ott, P Depeille, SM Wu, J Drost, R Nusse, JP Roose, J Piehler, SF Boj, CY Janda, H Clevers, CJ Kuo, KC Garcia
    Cell Stem Cell, 2020-08-19;0(0):.
    Species: Mouse
    Sample Types: Organoids, Whole Cells
    Applications: Bioassay
  30. Differential Histone Distribution Patterns in Induced Asymmetrically Dividing Mouse Embryonic Stem Cells
    Authors: B Ma, TJ Trieu, J Cheng, S Zhou, Q Tang, J Xie, JL Liu, K Zhao, SJ Habib, X Chen
    Cell Rep, 2020-08-11;32(6):108003.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
    Authors: L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
    Cell Stem Cell, 2020-08-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling
    Authors: SY Jeong, J Lyu, JA Kim, IH Oh
    Exp. Mol. Med., 2020-07-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  33. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
    Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
    Nat Commun, 2020-04-29;11(1):2082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction
    Authors: DP Bagchi, Z Li, CA Corsa, J Hardij, H Mori, BS Learman, KT Lewis, RL Schill, SM Romanelli, OA MacDougald
    Mol Metab, 2020-04-20;0(0):100992.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  35. Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways
    Authors: H Lee, YS Son, MO Lee, JW Ryu, K Park, O Kwon, KB Jung, K Kim, TY Ryu, A Baek, J Kim, CR Jung, CM Ryu, YJ Park, TS Han, DS Kim, HS Cho, MY Son
    Theranostics, 2020-04-06;10(11):5048-5063.
    Species: Mouse
    Sample Types: Colon
    Applications: Cell Culture
  36. Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing
    Authors: D Gay, G Ghinatti, CF Guerrero-J, RA Ferrer, F Ferri, CH Lim, S Murakami, N Gault, V Barroca, I Rombeau, P Mauffrey, L Irbah, E Treffeisen, S Franz, A Boissonnas, C Combadière, M Ito, MV Plikus, PH Romeo
    Sci Adv, 2020-03-20;6(12):eaay3704.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  37. Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis
    Authors: M Mecha, N Yanguas-Ca, A Feliú, L Mestre, FJ Carrillo-S, K Riecken, D Gomez-Nico, C Guaza
    J Neuroinflammation, 2020-03-19;17(1):88.
    Species: Rat
    Sample Types:
    Applications: Cell Culture
  38. Wnt signaling modulator DKK1 as an immunotherapeutic target in ovarian cancer
    Authors: I Betella, WJ Turbitt, T Szul, B Wu, A Martinez, A Katre, JA Wall, L Norian, MJ Birrer, R Arend
    Gynecol. Oncol., 2020-03-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  39. Engraftment potential of maternal adipose-derived stem cells for fetal transplantation
    Authors: A Kawashima, R Yasuhara, R Akino, K Mishima, M Nasu, A Sekizawa
    Heliyon, 2020-03-04;6(3):e03409.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  40. Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice
    Authors: Y Wada, A Kikuchi, A Kaga, N Shimizu, J Ito, R Onuma, F Fujishima, E Totsune, R Sato, T Niihori, M Shirota, R Funayama, K Sato, T Nakazawa, K Nakayama, Y Aoki, S Aiba, K Nakagawa, S Kure
    PLoS Genet., 2020-02-26;16(2):e1008628.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  41. High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis
    Authors: CJ Aros, MK Paul, CJ Pantoja, B Bisht, LK Meneses, P Vijayaraj, JM Sandlin, B France, JA Tse, MW Chen, DW Shia, TM Rickabaugh, R Damoiseaux, BN Gomperts
    Cell Rep, 2020-02-18;30(7):2055-2064.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  42. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells
    Authors: W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho
    Stem Cells, 2019-12-30;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/beta-Catenin signaling
    Authors: JP Sah, NTT Hao, X Han, TTT Tran, S McCarthy, Y Oh, JK Yoon
    Int. J. Biochem. Cell Biol., 2019-12-02;118(0):105661.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Sonic hedgehog connects podocyte injury to mesangial activation and glomerulosclerosis
    Authors: D Zhou, H Fu, Y Han, L Zhang, S Liu, L Lin, DB Stolz, Y Liu
    JCI Insight, 2019-11-14;4(22):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  45. The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation
    Authors: N Chen, RL Schill, M O'Donnell, K Xu, DP Bagchi, OA MacDougald, RJ Koenig, B Xu
    J. Biol. Chem., 2019-10-15;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Bioassay
  46. Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2
    Authors: FM Cernilogar, S Hasenöder, Z Wang, K Scheibner, I Burtscher, M Sterr, P Smialowski, S Groh, IM Evenroed, GD Gilfillan, H Lickert, G Schotta
    Nucleic Acids Res., 2019-09-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  47. NOD2 Supports Crypt Survival and Epithelial Regeneration after Radiation-Induced Injury
    Authors: C Lee, C Choi, HS Kang, SW Shin, SY Kim, HC Park, SN Hong
    Int J Mol Sci, 2019-09-02;20(17):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing
    Authors: S Saraswati, SMW Marrow, LA Watch, PP Young
    Nat Commun, 2019-07-09;10(1):3027.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  49. KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
    Authors: C Yoon, J Till, SJ Cho, KK Chang, JX Lin, CM Huang, S Ryeom, SS Yoon
    Mol. Cancer Res., 2019-06-19;0(0):.
    Species: Transgenic Mouse
    Sample Types: Organoid
    Applications: Bioassay
  50. L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams
    Authors: KL VanDussen, NM Sonnek, TS Stappenbec
    Stem Cell Res, 2019-03-27;37(0):101430.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Gfi1b regulates the level of Wnt/?-catenin signaling in hematopoietic stem cells and megakaryocytes
    Authors: P Shooshtari, A Helness, C Vadnais, N Brouwer, H Beauchemin, R Chen, H Bagci, FJT Staal, JF Coté, T Möröy
    Nat Commun, 2019-03-20;10(1):1270.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells
    Authors: M Chapellier, P Peña-Martí, R Ramakrishn, M Eriksson, M Safaee-Tal, C Orsmark-Pi, H Lilljebjör, C Högberg, A Hagström-A, T Fioretos, J Larsson, M Järås
    Haematologica, 2019-02-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects
    Authors: J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi
    Cell Rep, 2019-02-26;26(9):2494-2508.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice
    Authors: L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang
    Aging (Albany NY), 2018-12-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
    Authors: YB Hu, C Yan, L Mu, YL Mi, H Zhao, H Hu, XL Li, DD Tao, YQ Wu, JP Gong, JC Qin
    Oncogene, 2018-11-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Integrin-Rac signalling for mammary epithelial stem cell self-renewal
    Authors: S Olabi, A Ucar, K Brennan, CH Streuli
    Breast Cancer Res., 2018-10-22;20(1):128.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  57. WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
    Authors: A Yoney, F Etoc, A Ruzo, T Carroll, JJ Metzger, I Martyn, S Li, C Kirst, ED Siggia, AH Brivanlou
    Elife, 2018-10-12;7(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube
    Authors: Y Xie, ES Park, D Xiang, Z Li
    Stem Cell Res, 2018-08-25;32(0):51-60.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  59. Precardiac organoids form two heart fields via Bmp/Wnt signaling
    Authors: P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon
    Nat Commun, 2018-08-07;9(1):3140.
    Species: Mouse
    Sample Types:
  60. Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
    Authors: E López-Arri, V Rodilla, C Colomer, A Vert, A Shelton, JH Cheng, B Yan, A Gonzalez-P, MR Junttila, M Iglesias, F Torres, J Albanell, A Villanueva, A Bigas, CW Siebel, L Espinosa
    Nat Commun, 2018-07-31;9(1):2992.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  61. A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo
    Authors: A Spangler, EY Su, AM Craft, P Cahan
    Stem Cell Res, 2018-07-29;31(0):201-215.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle
    Authors: HE Ahrens, J Huettemeis, M Schmidt, C Kaether, J von Maltza
    Skelet Muscle, 2018-07-04;8(1):20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
    Authors: Y Muta, Y Fujita, K Sumiyama, A Sakurai, MM Taketo, T Chiba, H Seno, K Aoki, M Matsuda, M Imajo
    Nat Commun, 2018-06-05;9(1):2174.
    Species: Mouse
    Sample Types: Whole Tissue
  64. WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation
    Authors: K Matsuoka, Y Kohara, Y Naoe, A Watanabe, M Ito, K Ikeda, S Takeshita
    J. Bone Miner. Res., 2018-05-11;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea
    Authors: W Liu, X Xu, Z Fan, G Sun, Y Han, D Zhang, L Xu, M Wang, X Wang, S Zhang, M Tang, J Li, R Chai, H Wang
    Antioxid. Redox Signal., 2018-05-04;0(0):.
    Species: Mouse
    Sample Types: Tissue Explant
    Applications: Bioassay
  66. Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis
    Authors: JA Ríos, JA Godoy, NC Inestrosa
    Cell Commun. Signal, 2018-04-11;16(1):15.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC
    Authors: J Li, X Wu, Y Zhou, M Lee, L Guo, W Han, W Mo, WM Cao, D Sun, R Xie, Y Huang
    Nucleic Acids Res., 2018-04-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Targeting ?-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage
    Authors: A Held, A Glas, L Dietrich, M Bollmann, K Brandstädt, TN Grossmann, CH Lohmann, T Pap, J Bertrand
    Osteoarthr. Cartil., 2018-03-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Paracrine Wnt5a-?-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization
    Authors: F Zhao, C Xiao, KS Evans, T Theivanthi, N DeVito, A Holtzhause, J Liu, X Liu, D Boczkowski, S Nair, JW Locasale, BA Hanks
    Immunity, 2018-01-16;48(1):147-160.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  70. Establishment and characterization of five immortalized human scalp dermal papilla cell lines
    Authors: MH Kwack, JM Yang, GH Won, MK Kim, JC Kim, YK Sung
    Biochem. Biophys. Res. Commun., 2018-01-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial�Changes
    Authors: Y Kasagi, PM Chandramou, KA Whelan, K Tanaka, V Giroux, M Sharma, J Wang, AJ Benitez, M DeMarshall, JW Tobias, KE Hamilton, GW Falk, JM Spergel, AJ Klein-Szan, AK Rustgi, AB Muir, H Nakagawa
    Cell Mol Gastroenterol Hepatol, 2018-01-03;5(3):333-352.
    Species: Mouse
    Sample Types: Organoids
    Applications: Organoid Culture
  72. Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse
    Authors: Y Chen, H Xu, G Lin
    Cell Discov, 2017-12-19;3(0):17046.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice
    Authors: YY Sin, LL Ballantyne, CR Richmond, CD Funk
    Mol Ther Nucleic Acids, 2017-12-01;10(0):122-130.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates
    Authors: MW Susman, EP Karuna, RC Kunz, TS Gujral, AV Cantú, SS Choi, BY Jong, K Okada, MK Scales, J Hum, LS Hu, MW Kirschner, R Nishinakam, S Yamada, DJ Laird, LE Jao, SP Gygi, ME Greenberg, HH Ho
    Elife, 2017-09-08;6(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. N-terminal part of Dishevelled DEP domain is required for Wnt/?-catenin signaling in mammalian cells
    Authors: P Paclíková, O Bernatík, TW Radaszkiew, V Bryja
    Mol. Cell. Biol., 2017-08-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
    Authors: KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
    Nat Commun, 2017-08-24;8(1):331.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes
    Authors: B Li, C Dorrell, PS Canaday, C Pelz, A Haft, M Finegold, M Grompe
    Stem Cell Reports, 2017-07-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces
    Authors: M Lowndes, S Junyent, SJ Habib
    Nat Protoc, 2017-06-29;12(7):1498-1512.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
    Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
    Sci Rep, 2017-05-31;7(1):2585.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
    Authors: T Tammela, FJ Sanchez-Ri, NM Cetinbas, K Wu, NS Joshi, K Helenius, Y Park, R Azimi, NR Kerper, RA Wesselhoef, X Gu, L Schmidt, M Cornwall-B, ÖH Yilmaz, W Xue, P Katajisto, A Bhutkar, T Jacks
    Nature, 2017-05-10;545(7654):355-359.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Neuroprotective and regenerative roles of intranasal Wnt-3a Administration after focal ischemic stroke in mice
    Authors: ZZ Wei, JY Zhang, TM Taylor, X Gu, Y Zhao, L Wei
    J. Cereb. Blood Flow Metab., 2017-04-21;0(0):271678X177026.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  82. Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling
    Authors: Y Zhang
    Biochem. Biophys. Res. Commun., 2017-04-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
    Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
    Cell Stem Cell, 2017-03-30;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration
    Authors: K Wilk, SA Yeh, LJ Mortensen, S Ghaffariga, CM Lombardo, SH Bassir, ZA Aldawood, CP Lin, G Intini
    Stem Cell Reports, 2017-03-30;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Activation of Wnt3?/?-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation
    Authors: J Zhang, J Zhang, C Qi, P Yang, X Chen, Y Liu
    Biochem. Biophys. Res. Commun, 2017-03-25;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Acceleration of bone regeneration by activating Wnt/?-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis
    Authors: L Li, X Peng, Y Qin, R Wang, J Tang, X Cui, T Wang, W Liu, H Pan, B Li
    Sci Rep, 2017-03-24;7(0):45204.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling
    Authors: MB Furtado, JC Wilmanns, A Chandran, J Perera, O Hon, C Biben, TJ Willow, HT Nim, G Kaur, S Simonds, Q Wu, D Willians, E Salimova, N Plachta, JM Denegre, SA Murray, D Fatkin, M Cowley, JT Pearson, D Kaye, M Ramialison, RP Harvey, NA Rosenthal, MW Costa
    JCI Insight, 2017-03-23;2(6):e88271.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  88. Interplay between metabolic identities in the intestinal crypt supports stem cell function
    Authors: MJ Rodríguez-, M Schewe, M Meerlo, E Stigter, J Gerrits, M Pras-Raves, A Sacchetti, M Hornsveld, KC Oost, HJ Snippert, N Verhoeven-, R Fodde, BM Burgering
    Nature, 2017-03-08;543(7645):424-427.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways
    Authors: F Lacour, E Vezin, CF Bentzinger, MC Sincennes, L Giordani, A Ferry, R Mitchell, K Patel, MA Rudnicki, MC Chaboissie, AA Chassot, F Le Grand
    Cell Rep, 2017-03-07;18(10):2320-2330.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
    Authors: N Cerdá-Este, H Naumann, S Ruzittu, N Mah, IM Pongrac, C Cozzitorto, A Hommel, MA Andrade-Na, E Bonifacio, FM Spagnoli
    Nat Commun, 2017-02-13;8(0):14127.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.
    Authors: Lebensohn A, Dubey R, Neitzel L, Tacchelly-Benites O, Yang E, Marceau C, Davis E, Patel B, Bahrami-Nejad Z, Travaglini K, Ahmed Y, Lee E, Carette J, Rohatgi R
    Elife, 2016-12-20;5(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD
    Authors: Hoeke A Baarsma
    J. Exp. Med, 2016-12-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
    Nat. Med, 2016-12-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells
    Authors: Joan Massagué
    Cell Stem Cell, 2016-11-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Chemokine-Like Receptor 1 Is a Novel Wnt Target Gene that Regulates Mesenchymal Stem Cell Differentiation.
    Authors: Muruganandan S, Govindarajan R, McMullen N, Sinal C
    Stem Cells, 2016-11-11;35(3):711-724.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose
    PLoS ONE, 2016-09-23;11(9):e0163580.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism
    PLoS ONE, 2016-08-26;11(8):e0162049.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  98. Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a-induced Autophagy in Pancreatic Intraepithelial Neoplasms
    J Biol Chem, 2016-08-24;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Diverse Functions of Retinoic Acid in Brain Vascular Development
    J Neurosci, 2016-07-20;36(29):7786-801.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. WNT/?-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression
    Authors: Ting Cai
    Exp Cell Res, 2016-06-16;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  101. In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment
    Authors: PJ Attayek, AA Ahmad, Y Wang, I Williamson, CE Sims, ST Magness, NL Allbritton
    PLoS ONE, 2016-04-21;11(4):e0153795.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  102. Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation
    Authors: CM Karner, E Esen, J Chen, FF Hsu, J Turk, F Long
    J. Biol. Chem., 2016-04-20;291(25):13028-39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage
    Authors: Marie-Isabelle Garcia
    Development, 2016-03-17;143(9):1452-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Convergence of cMyc and beta-catenin on Tcf7l1 enables endoderm specification.
    Authors: Morrison G, Scognamiglio R, Trumpp A, Smith A
    EMBO J, 2015-12-16;35(3):356-68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Hepatic progenitor cells of biliary origin with liver repopulation capacity.
    Authors: Lu W, Bird T, Boulter L, Tsuchiya A, Cole A, Hay T, Guest R, Wojtacha D, Man T, Mackinnon A, Ridgway R, Kendall T, Williams M, Jamieson T, Raven A, Hay D, Iredale J, Clarke A, Sansom O, Forbes S
    Nat Cell Biol, 2015-07-20;17(8):971-83.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/beta-CATENIN SIGNALING PATHWAY.
    Authors: Beier E, Sheu T, Dang D, Holz J, Ubayawardena R, Babij P, Puzas J
    J Biol Chem, 2015-05-14;290(29):18216-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis.
    Authors: Amador-Arjona, Alejandr, Cimadamore, Flavio, Huang, Chun-Ten, Wright, Rebecca, Lewis, Susan, Gage, Fred H, Terskikh, Alexey V
    Proc Natl Acad Sci U S A, 2015-03-30;112(15):E1936-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.
    Authors: Chang B, Tessneer K, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy M, Rahman R, Ma J, Xia L, Chen H
    Nat Commun, 2015-03-16;6(0):6380.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. WNT/beta-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
    Authors: Suzuki A, Pelikan R, Iwata J
    Mol Cell Biol, 2015-03-09;35(10):1763-76.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  110. Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.
    Authors: Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo M, Manicassamy B, Koni P, Thangaraju M, Sun Z, Mellor A, Munn D, Manicassamy S
    J Immunol, 2015-02-20;194(7):3295-304.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W/+) mice.
    Authors: Zhang L, Chen P, Chen L, Weng T, Zhang S, Zhou X, Zhang B, Liu L
    PLoS ONE, 2015-02-18;10(2):e112716.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.
    Authors: Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler H, Kuhl M, Rudolph K
    EMBO J, 2015-01-21;34(5):624-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis.
    Authors: Alshbool F, Mohan S
    PLoS ONE, 2014-12-05;9(12):e114357.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway.
    Authors: Ramsey S, Vengrenyuk Y, Menon P, Podolsky I, Feig J, Aderem A, Fisher E, Gold E
    PLoS Genet, 2014-12-04;10(12):e1004828.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a in vitro.
    Authors: Ouji Y, Ishizaka S, Nakamura-Uchiyama F, Okuzaki D, Yoshikawa M
    J Invest Dermatol, 2014-12-01;135(6):1598-608.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection.
    Authors: Noguchi, H, Saitoh, I, Tsugata, T, Kataoka, H, Watanabe, M, Noguchi, Y
    Cell Death Differ, 2014-09-05;22(1):145-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  117. In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
    Authors: Gouti, Mina, Tsakiridis, Anestis, Wymeersch, Filip J, Huang, Yali, Kleinjung, Jens, Wilson, Valerie, Briscoe, James
    PLoS Biol, 2014-08-26;12(8):e1001937.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Custos controls beta-catenin to regulate head development during vertebrate embryogenesis.
    Authors: Komiya Y, Mandrekar N, Sato A, Dawid I, Habas R
    Proc Natl Acad Sci U S A, 2014-08-25;111(36):13099-104.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.
    Authors: Cambier L, Plate M, Sucov H, Pashmforoush M
    Development, 2014-08-01;141(15):2959-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  120. The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways.
    Authors: Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han J, Li J, Jing N
    Elife, 2014-06-14;3(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway.
    Authors: Gao B, Huang Q, Lin Y, Wei B, Guo Y, Sun Z, Wang L, Fan J, Zhang H, Han Y, Li X, Shi J, Liu J, Yang L, Luo Z
    PLoS ONE, 2014-06-11;9(6):e99137.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
    Authors: Zhu, Yunhua, Demidov, Oleg N, Goh, Amanda M, Virshup, David M, Lane, David P, Bulavin, Dmitry V
    J Clin Invest, 2014-06-09;124(7):3263-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
    Authors: Liu Y, Kaneda R, Leja T, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz R, Barahona M, Schneider M
    Stem Cells, 2014-06-01;32(6):1515-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Generation of organized germ layers from a single mouse embryonic stem cell.
    Authors: Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N
    Nat Commun, 2014-05-30;5(0):4000.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.
    Authors: Weinert S, Jabs S, Hohensee S, Chan W, Kornak U, Jentsch T
    EMBO Rep, 2014-05-12;15(7):784-91.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Manipulating gene expression and signaling activity in cultured mouse limb bud cells.
    Authors: Lewandowski J, Pursell T, Rabinowitz A, Vokes S
    Dev Dyn, 2014-04-17;243(7):928-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
    Authors: Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, Frenette J, Cornelison D, Rudnicki M
    J Cell Biol, 2014-04-07;205(1):97-111.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling.
    Authors: Koraishy F, Silva C, Mason S, Wu D, Cantley L
    J Biol Chem, 2014-04-01;289(20):14341-50.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis.
    Authors: Okamoto M, Udagawa N, Uehara S, Maeda K, Yamashita T, Nakamichi Y, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y
    Sci Rep, 2014-03-27;4(0):4493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4.
    Authors: Yu C, Nguyen T, Irvine K, Sweet M, Frazer I, Blumenthal A
    Eur J Immunol, 2014-03-07;44(5):1480-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors.
    Authors: Tsakiridis, Anestis, Huang, Yali, Blin, Guillaum, Skylaki, Stavroul, Wymeersch, Filip, Osorno, Rodrigo, Economou, Costas, Karagianni, Eleni, Zhao, Suling, Lowell, Sally, Wilson, Valerie
    Development, 2014-03-01;141(6):1209-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  132. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
    Authors: Go G, Srivastava R, Hernandez-Ono A, Gang G, Smith S, Booth C, Ginsberg H, Mani A
    Cell Metab, 2014-02-04;19(2):209-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  133. WNT7B promotes bone formation in part through mTORC1.
    Authors: Chen J, Tu X, Esen E, Joeng K, Lin C, Arbeit J, Ruegg M, Hall M, Ma L, Long F
    PLoS Genet, 2014-01-30;10(1):e1004145.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Beta-catenin is vital for the integrity of mouse embryonic stem cells.
    Authors: Raggioli A, Junghans D, Rudloff S, Kemler R
    PLoS ONE, 2014-01-21;9(1):e86691.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Canonical WNT signaling inhibits follicle stimulating hormone mediated steroidogenesis in primary cultures of rat granulosa cells.
    Authors: Stapp A, Gomez B, Gifford C, Hallford D, Hernandez Gifford J
    PLoS ONE, 2014-01-17;9(1):e86432.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells.
    Authors: Lei N, Jabaji Z, Wang J, Joshi V, Brinkley G, Khalil H, Wang F, Jaroszewicz A, Pellegrini M, Li L, Lewis M, Stelzner M, Dunn J, Martin M
    PLoS ONE, 2014-01-06;9(1):e84651.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Drugging a stem cell compartment using Wnt3a protein as a therapeutic.
    Authors: Dhamdhere, Girija R, Fang, Mark Y, Jiang, Jie, Lee, Katherin, Cheng, Du, Olveda, Rebecca, Liu, Bo, Mulligan, Kimberle, Carlson, Jeffery, Ransom, Ryan C, Weis, William, Helms, Jill A
    PLoS ONE, 2014-01-06;9(1):e83650.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells.
    Authors: Kohler, Erin E, Wary, Kishore, Li, Fei, Chatterjee, Ishita, Urao, Norifumi, Toth, Peter T, Ushio-Fukai, Masuko, Rehman, Jalees, Park, Changwon, Malik, Asrar B
    PLoS ONE, 2013-12-30;8(12):e85549.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  139. Pannexin 3 inhibits proliferation of osteoprogenitor cells by regulating Wnt and p21 signaling.
    Authors: Ishikawa M, Iwamoto T, Fukumoto S, Yamada Y
    J Biol Chem, 2013-12-12;289(5):2839-51.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.
    Authors: Boschert V, van Dinther M, Weidauer S, van Pee K, Muth E, ten Dijke P, Mueller T
    PLoS ONE, 2013-11-29;8(11):e81710.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease.
    Authors: Stalvey M, Clines K, Havasi V, McKibbin C, Dunn L, Chung W, Clines G
    PLoS ONE, 2013-11-13;8(11):e80098.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.
    Authors: Nishino, Jinsuke, Kim, Sunjung, Zhu, Yuan, Zhu, Hao, Morrison, Sean J
    Elife, 2013-11-05;2(0):e00924.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  143. Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with beta-catenin.
    Authors: Salazar V, Zarkadis N, Huang L, Watkins M, Kading J, Bonar S, Norris J, Mbalaviele G, Civitelli R
    J Cell Sci, 2013-10-07;126(0):5598-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling.
    Authors: Xavier C, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin J
    Cell Signal, 2013-09-28;26(1):94-101.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells.
    Authors: Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L
    Exp Cell Res, 2013-09-27;320(1):54-61.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection.
    Authors: Zhou, Wei-Jie, Geng, Zhen H, Spence, Jason R, Geng, Jian-Guo
    Nature, 2013-07-31;501(7465):107-11.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  147. Evidence for tankyrases as antineoplastic targets in lung cancer.
    Authors: Busch A, Johnson K, Stan R, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle S
    BMC Cancer, 2013-04-28;13(0):211.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  148. CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response.
    Authors: Huynh D, Akcora D, Malaterre J, Chan C, Dai X, Bertoncello I, Stanley E, Ramsay R
    PLoS ONE, 2013-02-22;8(2):e56951.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury.
    Proc Natl Acad Sci U S A, 2013-01-23;110(6):2324-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
    Authors: Mae, Shin-Ich, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhik, Kajiwara, Masatosh, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutosh, Nakayama, Naoki, Cowan, Chad A, Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P, Yamanaka, Shinya, Osafune, Kenji
    Nat Commun, 2013-01-01;4(0):1367.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Pertussis toxin-sensitive heterotrimeric G(alphai/o) proteins mediate WNT/beta-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.
    Authors: Halleskog C, Schulte G
    Cell Signal, 2012-12-22;25(4):822-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  152. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
    Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
    Nature, 2012-10-07;491(7426):765-8.
    Species: Mouse
    Sample Types: Whole Cells
  153. Prolactin stimulates precursor cells in the adult mouse hippocampus.
    Authors: Walker, Tara L, Vukovic, Jana, Koudijs, Margaret, Blackmore, Daniel G, Mackay, Eirinn W, Sykes, Alex M, Overall, Rupert W, Hamlin, Adam S, Bartlett, Perry F
    PLoS ONE, 2012-09-04;7(9):e44371.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration.
    Authors: Tran, Thanh H, Shi, Xiaofeng, Zaia, Joseph, Ai, Xingbin
    J Biol Chem, 2012-08-03;287(39):32651-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the beta-catenin destruction complex.
    Authors: Tran H, Polakis P
    J Biol Chem, 2012-07-03;287(34):28552-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  156. Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.
    Cell Death Differ., 2012-05-04;19(11):1761-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.
    Authors: Goel S, Chin EN, Fakhraldeen SA
    J. Biol. Chem., 2012-03-20;287(20):16454-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  158. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
    Authors: Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S
    Stem Cells Dev, 2012-02-29;21(12):2273-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).
    Authors: Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR
    J. Biol. Chem., 2012-02-15;287(15):12016-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA.
    Authors: Nakamura, Tetsuya, Saito, Daisuke, Kawasumi, Aiko, Shinohara, Kyosuke, Asai, Yasuko, Takaoka, Katsuyos, Dong, Fenglan, Takamatsu, Atsuko, Belo, Jose Ant, Mochizuki, Atsushi, Hamada, Hiroshi
    Nat Commun, 2012-01-01;3(0):1322.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  161. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells.
    Authors: Kelly OG, Chan MY, Martinson LA
    Nat. Biotechnol., 2011-07-31;29(8):750-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  162. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
    Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
    Stem Cells, 2011-06-01;29(6):964-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  163. Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.
    Authors: Krause C, Korchynskyi O, de Rooij K, Weidauer SE, de Gorter DJ, van Bezooijen RL, Hatsell S, Economides AN, Mueller TD, Lowik CW, ten Dijke P
    J. Biol. Chem., 2010-10-15;285(53):41614-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies.
    Authors: Gong Y, Bourhis E, Chiu C, Stawicki S, DeAlmeida VI, Liu BY, Phamluong K, Cao TC, Carano RA, Ernst JA, Solloway M, Rubinfeld B, Hannoush RN, Wu Y, Polakis P, Costa M
    PLoS ONE, 2010-09-13;5(9):e12682.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Binding Assay
  165. Notch and Wnt signaling mediated rod photoreceptor regeneration by Muller cells in adult mammalian retina.
    Authors: Del Debbio CB, Balasubramanian S, Parameswaran S, Chaudhuri A, Qiu F, Ahmad I
    PLoS ONE, 2010-08-26;5(8):e12425.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  166. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
    Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
    PLoS ONE, 2010-08-11;5(8):e12101.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  167. Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity.
    Authors: Trowbridge JJ, Guezguez B, Moon RT
    Stem Cells, 2010-08-01;28(8):1379-89.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
    Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
    Development, 2010-03-01;137(5):693-704.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  169. Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance.
    Authors: Gustafson B, Smith U
    J. Biol. Chem., 2010-02-23;285(18):14031-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Canonical Wnt signaling negatively regulates platelet function.
    Authors: Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB
    Proc. Natl. Acad. Sci. U.S.A., 2009-11-09;106(47):19836-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus.
    Authors: Gogolla N, Galimberti I, Deguchi Y, Caroni P
    Neuron, 2009-05-28;62(4):510-25.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  172. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
    Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
    Dev. Biol., 2009-04-07;330(2):286-304.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  173. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
    Authors: Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
    Cell Stem Cell, 2009-04-03;4(4):348-58.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  174. Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.
    Authors: Liu CC, Pearson C, Bu G
    J. Biol. Chem., 2009-03-31;284(22):15299-307.
    Species: Human
    Sample Types: N/A, Whole Cells
    Applications: Bioassay, Receptor Binding Assay
  175. H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation.
    Authors: Kim SE, Yoon JY, Jeong WJ, Jeon SH, Park Y, Yoon JB, Park YN, Kim H, Choi KY
    J. Cell. Sci., 2009-02-24;122(0):842-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  176. Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element.
    Authors: Shafer SL, Towler DA
    J. Mol. Cell. Cardiol., 2009-01-21;46(5):621-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  177. Parathyroid hormone signaling through low-density lipoprotein-related protein 6.
    Authors: Wan M, Yang C, Li J, Wu X, Yuan H, Ma H, He X, Nie S, Chang C, Cao X
    Genes Dev., 2008-11-01;22(21):2968-79.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  178. The microRNA miR-8 is a conserved negative regulator of Wnt signaling.
    Authors: Kennell JA, Gerin I, MacDougald OA, Cadigan KM
    Proc. Natl. Acad. Sci. U.S.A., 2008-09-29;105(40):15417-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.
    Authors: Verkaar F, van Rosmalen JW, Smits JF, Blankesteijn WM, Zaman GJ
    Cell. Signal., 2008-09-25;21(1):22-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  180. Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium.
    Authors: Nakanishi M, Kurisaki A, Hayashi Y, Warashina M, Ishiura S, Kusuda-Furue M, Asashima M
    FASEB J., 2008-09-22;23(1):114-22.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.
    Authors: Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS
    Mol. Cell. Biol., 2008-01-22;28(7):2368-79.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  182. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.
    Authors: Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L
    Genes Dev., 2008-01-15;22(2):152-65.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  183. Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus.
    Authors: Anderson BC, Christiansen SP, McLoon LK
    Invest. Ophthalmol. Vis. Sci., 2008-01-01;49(1):221-9.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: In Vivo
  184. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells.
    Authors: Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK
    Biochem. Biophys. Res. Commun., 2007-12-04;366(1):129-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
    Authors: Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H
    Blood, 2007-11-27;111(4):1933-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  186. Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment.
    Authors: Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Donofrio G, Bonomini S, Sala R, Mangoni M, Rizzoli V
    Cancer Res., 2007-08-15;67(16):7665-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  187. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
    Authors: Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D
    Proc. Natl. Acad. Sci. U.S.A., 2007-06-18;104(26):10894-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  188. Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia.
    Authors: Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel-Ramoya A, Canalis E
    J. Biol. Chem., 2007-05-10;282(27):19762-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Wnt3a binds to several sFRPs in the nanomolar range.
    Authors: Wawrzak D, Metioui M, Willems E, Hendrickx M, de Genst E, Leyns L
    Biochem. Biophys. Res. Commun., 2007-04-19;357(4):1119-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
    Authors: Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M
    Proc. Natl. Acad. Sci. U.S.A., 2007-03-19;104(13):5668-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity.
    Authors: Canning CA, Lee L, Irving C, Mason I, Jones CM
    Dev. Biol., 2007-02-16;305(1):276-86.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  192. An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity.
    Authors: Nordstrom U, Maier E, Jessell TM, Edlund T
    PLoS Biol., 2006-07-01;4(8):e252.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  193. Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia.
    Authors: Yue Z, Jiang TX, Widelitz RB, Chuong CM
    Proc. Natl. Acad. Sci. U.S.A., 2006-01-17;103(0):951-5.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  194. Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells.
    Authors: Corti S, Locatelli F, Papadimitriou D, Donadoni C, Del Bo R, Fortunato F, Strazzer S, Salani S, Bresolin N, Comi GP
    FASEB J., 2005-09-08;19(13):1860-2.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Mouse Wnt-3a Protein
By Xun Lin on 06/16/2020
Application: Stem/Immune cell maintenance or differentiation
Recombinant Mouse Wnt-3a Protein
By Zheng Wei on 10/25/2017
Application: In vivo study
In vivo study Recombinant Mouse Wnt-3a Protein 1324-WN
Recombinant Mouse Wnt-3a Protein
By Anonymous on 09/08/2017
Application: In vivo study
Recombinant Mouse Wnt-3a Protein
By James Waire on 05/16/2017
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: Consistent and expect bioactive in our cell culture assays. Also expected protein concentration

Use rec Wnt in the growth and differentiation of cultures.

Recombinant Mouse Wnt-3a Protein
By Anonymous on 07/21/2016
Application: Stem/Immune cell maintenance or differentiation
Recombinant Mouse Wnt-3a Protein
By Anonymous on 05/17/2016
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: reproducible results