RGDS peptide
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Description: Integrin binding sequence; inhibits integrin receptor function
Purity: ≥95%
Biological Activity
RGDS peptide is an integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.Technical Data
M.Wt:
433.42
Formula:
C15H27N7O8
Sequence:
RGDS
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
91037-65-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Apoptosis and survival of osteoblast-like cells are regulated by surface attachment.
Grigoriou et al.
J.Biol.Chem., 2005;280:1733 -
Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways.
Moon et al.
Respir.Res., 2009;10:18 -
Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to CTGF/CCN2 due to an increase in the levels of endogenous fibronectin.
Droppelmann et al.
J.Biol.Chem., 2009;284:13551
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Citations for RGDS peptide
The citations listed below are publications that use Tocris products. Selected citations for RGDS peptide include:
14 Citations: Showing 1 - 10
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Inhibition of Integrin αvβ6 Activation of TGF-β Attenuates Tendinopathy.
Authors: Tao Et al.
Adv Sci (Weinh) 2022;9:e2104469
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Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina.
Authors: Anne Et al.
Dev Cell 2022;57:2321-2333.e9
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The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis.
Authors: Marko Et al.
Front Oncol 2022;12:777634
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Pancreatic Stellate Cells Prolong Ex Vivo Islet Viability and Function and Improve Engraftment.
Authors: Pradyut K Et al.
Stem Cells Transl Med 2022;11:630-643
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β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells.
Authors: Paul C Et al.
Sci Rep 2020;10:12644
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Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.
Authors: Baghdadi
Nature 2018;557:714
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Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.
Authors: Sean P Et al.
Cancer Cell 2018;34:659-673.e6
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Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Authors: Keasey Et al.
J Cell Sci 2018;131
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Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis.
Authors: Bian Et al.
Bone Res 2017;5:17008
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Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation.
Authors: Conant
J Neuroinflammation 2017;14(1):56
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Dopamine increases NMDA-stimulated calcium flux in striatopallidal neurons through a matrix metalloproteinase-dependent mechanism.
Authors: Yan Et al.
Eur J Neurosci 2016;43:194-203
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Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Authors: Visavadiya
Cell Communication and Signaling 2016;14:32
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Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells.
Authors: Ahmed Et al.
J Radiat Res 2015;2:85
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Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
Authors: Kang Et al.
J Neurosci 2012;32:9277
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