Riluzole hydrochloride

Catalog #: 0768
15 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0768/25

Riluzole hydrochloride | CAS No. 850608-87-6 | Glutamate Receptor Inhibitors

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Description: GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels

Chemical Name: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride

Purity: ≥98%

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Product Details

Citations (15)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Inhibits glutamate release from presynaptic terminals and increases Na⁺-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na⁺ channels and inhibits GABA uptake by striatal synaptosomes. Also activates TRPC5 channels. Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic, anesthetic and neuroprotective properties.

Technical Data

M.Wt:

270.66

Formula:

C₈H₅F₃N₂OS.HCl

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming

Purity:

≥98%

Storage:

Store at RT

CAS No:

850608-87-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Na⁺ channels as targets for neuroprotective drugs.
Taylor and Meldrum
TiPS, 1995;16:309
Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.
Fumagalli et al.
Eur.J.Pharmacol., 2008;578:171
Riluzole activates TRPC5 channels independently of PLC activity.
Richter et al.
Br.J.Pharmacol., 2014;171:158
Differential action of Riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.
Song et al.
J.Pharmacol.Exp.Ther., 1997;282:707
Inhibition by Riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones.
Umeniya and Berger
Br.J.Pharmacol., 1995;116:3227

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Citations for Riluzole hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Riluzole hydrochloride include:

15 Citations: Showing 1 - 10

Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Authors: Zhang Et al.
Neuron 2018;98:918
Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer.
Authors: Sexton Et al.
Sci Rep 2018;8:16008
Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.
Authors: Shin Et al.
Oncogenesis 2018;7:86
Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells.
Authors: Sperling Et al.
Oncotarget 2017;8:96697
R.zole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells.
Authors: Dolfi Et al.
Oncotarget 2017;8:44639
Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression.
Authors: Rosenberg Et al.
Front Neural Circuits 2015;8:42614
Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
Authors: Du Et al.
Nat Commun 2015;6:6626
Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
Authors: Du Et al.
Nat.Commun. 2015;6:6626
Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
Authors: Veettil Et al.
PLoS Pathog 2014;10:e1004389
β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro.
Authors: Viemari Et al.
Neurochem Int 2013;7:179

Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons.
Authors: Park Et al.
J Neurophysiol 2013;109:1378

R.zole elevates GLT-1 activity and levels in striatal astrocytes.
Authors: Carbone Et al.
BMC Neurosci 2012;60:42613

R.zole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation.
Authors: Carbone Et al.
Cells 2012;13:38

Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse.
Authors: Morgado-Valle Et al.
J Neurosci 2010;30:3634

The glutamate release inhibitor R.zole decreases migration, invasion, and proliferation of melanoma cells.
Authors: Le Et al.
J Invest Dermatol 2010;130:2240

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