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RIPA 56

Catalog #: 7339 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7339/50
7339/10
RIPA 56 | CAS No. 1956370-21-0 | RIP Kinase Inhibitors
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Description: Potent and metabolically stable RIP1 kinase inhibitor

Chemical Name: N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide

Purity: ≥98%

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Biological Activity

RIPA 56 is a potent and metabolically stable receptor-interacting protein kinase 1 (RIPK1) inhibitor (EC50 = 13 nM). RIPA-56 shows no inhibition of RIP3 kinase at 10 μM. RIPA 56 blocks necroptosis and aging of the mouse male reproductive system. RIPA 56 reduces tumor necrosis factor α (TNFα)-induced mortality and multi-organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). RIPA 56 is orally bioavailable.

Technical Data

M.Wt:
221.3
Formula:
C13H19NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1956370-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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