Ritanserin
Chemical Name: 6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Purity: ≥98%
Biological Activity
Ritanserin is a potent and long-acting 5-HT2 receptor antagonist (Ki = 0.39 nM). Anxiolytic in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Receptor-binding properties in vitro and in vivo of ritanserin.
Leysen et al.
Mol.Pharmacol., 1985;27:600 -
Pharmacology of potent and selective S2-serotonergic antagonists.
Janssen
J.Cardiovasc.Pharmacol., 1985;7:S2 -
Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives.
Watanabe et al.
J.Med.Chem., 1992;35:189
Product Datasheets
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Citations for Ritanserin
The citations listed below are publications that use Tocris products. Selected citations for Ritanserin include:
7 Citations: Showing 1 - 7
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Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats.
Authors: Shimizu Et al.
Br J Pharmacol 2017;174:3072
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The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
Authors: Bracha Et al.
Physiol Behav 2013;9:251
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Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons.
Authors: Mondal Et al.
PLoS One 2013;8:e60365
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A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
Authors: Jahchan Et al.
Cancer Discov 2013;3:1364
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Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.
Authors: Chen Et al.
J Biol Chem 2012;287:5059
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Pharmacological stimulation of locus coeruleus reveals a new antipsychotic-responsive pathway for deficient sensorimotor gating.
Authors: Alsene and Bakshi
Neuropsychopharmacology 2011;36:1656
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Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
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