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RN 1 dihydrochloride

Catalog #: 4977
1 Citation Datasheet / COA / SDS
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4977/10
4977/50
RN 1 dihydrochloride | CAS No. 1781835-13-9 | Histone Demethylase Inhibitors
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Description: LSD1 inhibitor

Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RN 1 dihydrochloride is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

Technical Data

M.Wt:
452.42
Formula:
C23H29N3O2.2HCl
Solubility:
Soluble to 20 mM in water and to 20 mM in DMSO with gentle warming
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1781835-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Brain-penetrant LSD1 inhibitors can block memory consolidation.
    Neelamegam et al.
    ACS Chem.Neurosci., 2012;3:120

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Citation for RN 1 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for RN 1 dihydrochloride include:

1 Citation: Showing 1 - 1

  1. HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
    Authors: Llewellyn Et al.
    J Neurovirol  2018;24:192

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