Home / TRPV Agonists / RN 1747

RN 1747

Catalog #: 3745
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3745/10
3745/50
RN 1747 | CAS No. 1024448-59-6 | TRPV Agonists
1 Image
Description: Selective TRPV4 agonist

Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RN 1747 is a selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).

Technical Data

M.Wt:
395.87
Formula:
C17H18ClN3O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1024448-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and characterization of novel TRPV4 modulators.
    Vincent et al.
    Biochem.Biophys.Res.Comms., 2009;389:490

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for RN 1747

The citations listed below are publications that use Tocris products. Selected citations for RN 1747 include:

4 Citations: Showing 1 - 4

  1. Dysregulation of TRPV4, eNOS and caveolin-1 contribute to endothelial dysfunction in the streptozotocin rat model of diabetes.
    Authors: Christopher D Et al.
    Eur J Pharmacol  2020;888:173441
  2. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
    Authors: Shi Et al.
    Am J Physiol Renal Physiol  2015;21:4852
  3. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats.
    Authors: Vizin Et al.
    Acta Physiol  2015;214:275
  4. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    World J Gastroenterol  2013;305:F396

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for RN 1747

There are currently no reviews for this product. Be the first to review RN 1747 and earn rewards!

Have you used RN 1747?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.