Ro 20-1724
Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Purity: ≥99%
Biological Activity
Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
Ahluwalia and Nicholson et al.
TiPS, 1991;12:19 -
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
Soderling et al.
Proc.Natl.Acad.Sci.U.S.A., 1998;95:8991 -
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle.
Reeves et al.
Biochem.J., 1987;241:535
Product Datasheets
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Citations for Ro 20-1724
The citations listed below are publications that use Tocris products. Selected citations for Ro 20-1724 include:
3 Citations: Showing 1 - 3
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Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier.
Authors: Winger Et al.
J Immunol 2014;193:2427
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Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference.
Authors: Zhong Et al.
Neuropsychopharmacology 2012;37:2377
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Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs.
Authors: Peters Et al.
J Biomol Screen 2007;12:312
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