Home / Cyclin-dependent Kinase Inhibitors / Roscovitine

Roscovitine

Catalog #: 1332 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1332/10
1332/50
Roscovitine | CAS No. 186692-46-6 | Cyclin-dependent Kinase Inhibitors
1 Image
Description: Cdk inhibitor
Alternative Names: CYC 202,Seliciclib

Chemical Name: (2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Roscovitine is a cyclin-dependent kinase (cdk) inhibitor. Displays sub-micromolar inhibition of cdk1, cdk2, cdk5, cdk7 and cdk9 (reported IC50 values range from 0.16 - 0.28 μM for cdk5 to 0.8 μM for cdk7). Selective for cdks over a wide range of related kinases including ERK1 and ERK2. Arrests L1210 cells in G1 phase. Inhibits phosphorylation of vimentin in vivo. Antimitotic.

Technical Data

M.Wt:
354.45
Formula:
C19H26N6O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
186692-46-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
    Jorda et al.
    J.Med.Chem., 2018;61:9105
  2. Inhibition of cyclin-dependent kinases by purine analogues.
    De Azevedo et al.
    Eur.J.Biochem., 1997;243:518
  3. Chemical inhibitors of cyclin-dependent kinases.
    Meijer
    Trends Cell.Biol., 1996;6:393
  4. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
    Meijer et al.
    Eur.J.Biochem., 1997;243:527
  5. Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin
    F Agasse, I Mendez-Dav, W Christalle, R Carpentier, BY Braz, DJ David, F Saudou, S Humbert
    Cell Rep, 2020;32(1):107865.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Roscovitine

There are currently no reviews for this product. Be the first to review Roscovitine and earn rewards!

Have you used Roscovitine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.