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Rufinamide

Catalog #: 3828 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3828/10
3828/50
Rufinamide | CAS No. 106308-44-5 | Additional Voltage-gated Sodium Channel Products
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Description: Prolongs inactivation of sodium channels; anticonvulsant
Alternative Names: CGP 33101

Chemical Name: 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide

Purity: ≥99%

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Biological Activity

Rufinamide is a board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.

Technical Data

M.Wt:
238.19
Formula:
C10H8F2N4O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
106308-44-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Rufinamide.
    Arroyo
    Neurotherapeutics, 2007;4:155
  2. Diverse mechanisms of antiepileptic drugs in the development pipeline.
    Rogawski et al.
    Epilepsy Res., 2006;69:273
  3. The anticonvulsant profile of rufin. (CGP 33101) in rodent seizure models.
    White et al.
    Epilepsia, 2008;49:1213

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