Ruthenium Red

Catalog #: 1439
18 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1439/100

Ruthenium Red | CAS No. 11103-72-3 | Cav2.x Channel Blockers

1 Image

Description: Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels

Chemical Name: Ammoniated ruthenium oxychloride

View All Products for Cav2.x Channel Blockers

Product Details

Citations (18)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ruthenium Red blocks Ca²⁺ uptake and release from mitochondria, and Ca²⁺ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC₅₀ = 14 nM) and voltage-sensitive Ca²⁺ channels to inhibit neurotransmitter release.

Technical Data

M.Wt:

786.35

Formula:

H₄₂N₁₄O₂Ru₃Cl₆

Solubility:

Soluble to 10 mM in water

Storage:

Store at RT

CAS No:

11103-72-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red.
Bernardi et al.
Biochemistry, 1984;23:1645
Ruthenium red as a capsaicin antagonist.
Amann and Maggi
Life Sci., 1991;49:849
Vanilloid (capsaicin) receptors and mechanisms.
Szallasi and Blumberg
Pharmacol.Rev., 1999;51:159
Ruthenium red modifies the cardiac and skeletal muscle Ca²⁺ release channels (ryanodine receptors) by multiple mechanisms.
Xu et al.
J.Biol.Chem., 1999;274:32680

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Ruthenium Red

The citations listed below are publications that use Tocris products. Selected citations for Ruthenium Red include:

18 Citations: Showing 1 - 10

High-Frequency Microdomain Ca²⁺ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease.
Authors: P?rez
Redox Biol 2018;19:290
Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.
Authors: Fernandez-Fernandez Et al.
PLoS One 2018;13:e0199282
BH3 mimetic-elicited Ca²⁺ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca²⁺-like peptides.
Authors: Ferdek Et al.
Cell.Death.Dis. 2017;8:e2640
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
Authors: Russo Et al.
The Journal of Immunology 2016;197:1353
Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells.
Authors: Son Et al.
J Dent Res 2015;94:473
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
Proc Natl Acad Sci U S A 2015;21:4852
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
Authors: Merino Et al.
Neuroreport 2015;10:e0132884
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
Authors: Lee Et al.
PLoS One 2014;111:E5114
Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
Authors: Nesuashvili Et al.
Mol Pharmacol 2013;83:1007

Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons.
Authors: Boychuk Et al.
Front Neurosci 2013;7:3

Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
Authors: Kaszás Et al.
J Neurosci 2012;340:152

TRPV4 channels mediate the infrared laser-evoked response in sensory neurons.
Authors: Albert Et al.
J Neurophysiol 2012;107:3227

TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.
Authors: Li Et al.
Environ Health Perspect 2011;119:784

Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells.
Authors: Giordano Et al.
Toxicol Sci 2007;100:433

Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores.
Authors: Jacques-Fricke Et al.
World J Gastroenterol 2006;26:5656

Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation.
Authors: Moran Et al.
J Neurophysiol 2004;92:3266

Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons.
Authors: Melis Et al.
J Neurosci 2004;24:10707

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Ruthenium Red

There are currently no reviews for this product. Be the first to review Ruthenium Red and earn rewards!

Have you used Ruthenium Red?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.