SAK 3

Catalog #: 6239 Datasheet / COA / SDS

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SAK 3 | CAS No. 1256269-87-0 | Cav3.x Channel Activators

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Description: Potent CaV3.1 and 3.3 activator; orally bioavailable

Chemical Name: Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate

Purity: ≥98%

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Biological Activity

SAK 3 is a potent Ca_V3.1 and Ca_V3.3 activator. Enhances Ca_V3.1 and Ca_V3.3, but not Ca_V3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.

Technical Data

M.Wt:

369.41

Formula:

C₂₀H₂₃N₃O₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1256269-87-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacological properties of SAK3, a novel T-type voltage-gated Ca²⁺ channel enhancer.
Yabuki et al.
Neuropharmacology, 2017;117:1
T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice.
Xu et al.
J.Pharmacol.Sci., 2018;137:333

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