Santacruzamate A
Chemical Name: Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate
Purity: ≥98%
Biological Activity
Santacruzamate A is a highly potent and selective histone deactylase 2 (HDAC2) inhibitor (IC50 = 112 - 119 pM). Also inhibits HDAC6 in nanomolar range (IC50 = 433 nM). Displays >3500 fold selectivity for HDAC2 over HDAC6, and >8500-fold selectivity over HDAC4 (IC50 >1 μM for HDAC4). Inhibits growth of HuT-78 cutaneous T-cell lymphoma cell line. Identified as targeting human host proteins that interact with SARS-CoV-2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Gordon et al.
Nature, 2020; -
Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.
Pavlik et al.
J.Nat.Prod., 2013;76:2026
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Citation for Santacruzamate A
The citations listed below are publications that use Tocris products. Selected citations for Santacruzamate A include:
1 Citation: Showing 1 - 1
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INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury.
Authors: Steven L Et al.
Nat Commun 2022;13:6037
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