SB 297006

Catalog #: 4213 Datasheet / COA / SDS

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SB 297006 | CAS No. 58816-69-6 | Chemokine Receptor Antagonists

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Description: Potent and selective CCR3 antagonist

Chemical Name: N-Benzoyl-4-nitroaniline ethyl ester

Purity: ≥99%

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Biological Activity

SB 297006 is a potent and selective CCR3 antagonist (IC₅₀ = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC₅₀ >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC₅₀ values are 80, 90 and 210 nM respectively).

Technical Data

M.Wt:

342.35

Formula:

C₁₈H₁₈N₂O₅

Solubility:

Soluble to 100 mM in DMSO and to 20 mM in ethanol

Purity:

≥99%

Storage:

Store at RT

CAS No:

58816-69-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Quantitative structure-activity relationships of D- and L-N-actyl-alpha-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers.
Yoshimoto and Hansch
J.Org.Chem., 1976;41:2269
Identification of a potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.
White et al.
J.Biol.Chem., 2000;275:36626

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