SB 328437
Chemical Name: N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester
Purity: ≥99%
Biological Activity
SB 328437 is a potent and selective CCR3 antagonist (IC50 = 4 nM). Displays > 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca2+ mobilization (IC50 values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation.
Abonyo BO, Alexander MS, Heiman AS.
Am J Physiol Lung Cell Mol Physiol. -
Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.
White et al.
J.Biol.Chem., 2000;275:36626 -
Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.
Mori et al.
Int.Immunol., 2007;19:913
Product Datasheets
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Citations for SB 328437
The citations listed below are publications that use Tocris products. Selected citations for SB 328437 include:
2 Citations: Showing 1 - 2
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Blocking the autocrine regulatory loop of Gankyrin/STAT3/CCL24/CCR3 impairs the progression and pazopanib resistance of clear cell renal cell carcinoma.
Authors: Jing Et al.
Cell Death Dis 2020;11:117
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Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue.
Authors: Christoph Et al.
Immunology 2012;137:80-8
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