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SB 612111 hydrochloride

Catalog #: 3573
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3573/10
3573/50
SB 612111 hydrochloride | NOP Receptor Antagonists
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Description: Selective NOP antagonist

Chemical Name: (5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride

Purity: ≥97%

Product Details
Citations (2)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SB 612111 hydrochloride is a selective NOP receptor antagonist (Ki values are 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively). Antagonizes the pronociceptive action of nociceptin (Cat. No. 0910) in an acute pain model. Potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model.

Technical Data

M.Wt:
454.86
Formula:
C24H29Cl2NO.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

Background References

  1. Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area.
    Parsons, Matthew, Burt, Julia, Cranford, Amanda, Alberto, Christia, Zipperlen, Katrin, Hirasawa, Michiru
    PLoS ONE, 2012;7(9):e45350.
  2. Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies.
    Spagnolo et al.
    J.Pharm.Exp.Ther., 2007;106:961
  3. Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies.
    Rizzi et al.
    J.Pharmacol.Exp.Ther., 2007;321:968
  4. Modification of nociception and mor. tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)
    Zaratin et al.
    J.Pharmacol.Exp.Ther., 2004;308:454

Product Datasheets

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Citations for SB 612111 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 612111 hydrochloride include:

2 Citations: Showing 1 - 2

  1. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists.
    Authors: Michael R Et al.
    Sci Signal  2019;12
  2. Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating.
    Authors: Hardaway Et al.
    Behav Brain Res  2016;307:25

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