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SC 560

Catalog #: 1550
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SC 560 | CAS No. 188817-13-2 | Cyclooxygenase Inhibitors
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Description: Cyclooxygenase-1 (COX-1) inhibitor

Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SC 560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.

Technical Data

M.Wt:
352.74
Formula:
C17H12ClF3N2O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
188817-13-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer.
    Daikoku et al.
    Cancer Res., 2005;65:3735
  2. COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events.
    Takeuchi et al.
    Curr.Top.Med.Chem., 2005;5:475
  3. Pharmacological analysis of cyclooxygenase-1 in inflammation.
    Smith et al.
    Proc Natl Acad Sci U S A, 1998;95:13313
  4. Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases
    S Gaertner, C Auger, MA Farooq, B Pollet, S Khemais-Be, ZR Niazi, S Schrevens, SH Park, F Toti, D Stephan, VB Schini-Ker
    Int J Mol Sci, 2020;21(3):.

Product Datasheets

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Citation for SC 560

The citations listed below are publications that use Tocris products. Selected citations for SC 560 include:

1 Citation: Showing 1 - 1

  1. Prostaglandin-dependent modulation of DArgic neurotransmission elicits inflammation-induced aversion in mice.
    Authors: Fritz Et al.
    J Clin Invest  2016;126:695

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