Home / Akt (Protein Kinase B) Activators / SC 79

SC 79

Catalog #: 4635
11 Citations 1 Review Datasheet / COA / SDS
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4635/50
SC 79 | CAS No. 305834-79-1 | Akt (Protein Kinase B) Activators
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Description: Akt activator

Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

Product Details
Citations (11)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

Technical Data

M.Wt:
364.78
Formula:
C17H17ClN2O5
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
305834-79-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SC 79

The citations listed below are publications that use Tocris products. Selected citations for SC 79 include:

11 Citations: Showing 1 - 10

  1. Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication.
    Authors: Lucie Et al.
    Viruses  2022;14
  2. FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.
    Authors: Yutao Et al.
    Dev Dyn  2021;250:134-144
  3. Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
    Authors: Marc Et al.
    J Biol Chem  2020;295:16906-16919
  4. Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
    Authors: Marc Et al.
    J Biol Chem  2020;295:16906-16919
  5. Engineered antibody-functionalized porous silicon nanoparticles for therapeutic targeting of pro-survival pathway in endogenous neuroblasts after stroke.
    Authors: Andrii Et al.
    Biomaterials  2020;227:119556
  6. GIV/Girdin promotes cell survival during endoplasmic reticulum stress.
    Authors: Peter Et al.
    Mol Cell Biochem  2019;453:79-88
  7. Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.
    Authors: Wang Et al.
    Stem Cell Res Ther  2017;8:245
  8. miR-382 targeting PTEN-Akt axis promotes liver regeneration.
    Authors: Bei Et al.
    Mol Syst Biol  2016;7:1584
  9. SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
    Authors: Wilson Et al.
    Sci Rep  2016;6:17735
  10. A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
    Authors: Moreira Et al.
    J Transl Med  2015;13:76
  11. The bimodally expressed microRNA miR-142 gates exit from pluripotency.
    Authors: Sladitschek and Neveu
    Sci Rep  2015;11:850

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in vitro teatment
By Anonymous on 04/05/2019
Species: Mouse

Cells were treated with 5 um SC79 to activate AKT

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