Home / Na+/Ca2+ Exchanger Inhibitors / SEA 0400

SEA 0400

Catalog #: 6164
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6164/50
6164/10
SEA 0400 | CAS No. 223104-29-8 | Na+/Ca2+ Exchanger Inhibitors
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Description: Potent Na+/Ca2+ exchanger (NCX) inhibitor

Chemical Name: 2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC50 values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.

Technical Data

M.Wt:
371.38
Formula:
C21H19F2NO3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
223104-29-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SEA 0400

The citations listed below are publications that use Tocris products. Selected citations for SEA 0400 include:

3 Citations: Showing 1 - 3

  1. NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages.
    Authors: Neubert Et al.
    PLoS Biol  2020;18
  2. Intracellular Ca2+ Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency.
    Authors: Bradley J Et al.
    Cell Stem Cell  2019;25:210-224.e6
  3. Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death.
    Authors: Yan Et al.
    Br J Pharmacol  2019;176:2691-2707

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