Home / Protein Arginine Methyltransferase Inhibitors / SGC 6870

SGC 6870

Catalog #: 7182 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7182/25
7182/5
SGC 6870 | CAS No. 2561471-27-8 | Protein Arginine Methyltransferase Inhibitors
1 Image
Description: Potent and selective PRMT6 allosteric inhibitor

Chemical Name: (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

Purity: ≥98%

Product Details
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

SGC 6870 is a potent and selective protein arginine methyltransferase 6 (PRMT6) allosteric inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC50 = 0.8 μM)

Negative control SGC 6870N (Cat. No. 7184) also available.

Technical Data

M.Wt:
469.4
Formula:
C23H21BrN2O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2561471-27-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 6870 probe summary on the SGC website.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SGC 6870

There are currently no reviews for this product. Be the first to review SGC 6870 and earn rewards!

Have you used SGC 6870?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.