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SGC CK2-1

Catalog #: 7450
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7450/10
7450/50
SGC CK2-1 | CAS No. 2470424-39-4 | Casein Kinase 2 Inhibitors
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Description: Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2

Chemical Name: N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

SGC CK2-1 is a potent inhibitor of casein kinase 2 (CK2) with activity at both the CK2A2 and CK2A1 isoforms (IC50 values are 2.3-16 nM and 4.2-36 nM respectively). SGC CK-1 also inhibits DYRK2 (IC50 = 440 nM).

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC CK2-1 is reviewed on the chemical probes website.

Technical Data

M.Wt:
375.44
Formula:
C20H21N7O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2470424-39-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CK2-1 probe summary on the SGC website.

Product Datasheets

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Citation for SGC CK2-1

The citations listed below are publications that use Tocris products. Selected citations for SGC CK2-1 include:

1 Citation: Showing 1 - 1

  1. Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy.
    Authors: Carmine Et al.
    Sci Adv  2022;8:eabo1215

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