Simple Plex Control for Human ASC

Catalog #: 898571 Datasheet / COA / SDS

Control for use with Human ASC Simple Plex Cartridge Kit

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898571

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Simple Plex Control for Human ASC Summary

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human ASC concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

Specifications

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Species

Human

Product Datasheets

Product Datasheet

Background: ASC

ASC contains an N-terminal Pyrin domain and C-terminal CARD (Caspase-recruitment Domain), and is a p53 target protein that serves as an adaptor to the pro-apoptotic Bax molecule. The interaction of ASC with Bax promotes apoptosis in response to many apoptotic stimuli. Methylation of the ASC gene has been correlated with decreased protein expression in numerous types of cancer.

Long Name

Apoptosis-Associated Speck-Like Protein Containing A CARD

Entrez Gene IDs

29108 (Human)

Alternate Names

apoptosis-associated speck-like protein containing a CARD; ASC; CARD5; caspase recruitment domain protein 5; Caspase recruitment domain-containing protein 5; hASC; PYCARD; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1; TMS; TMS1; TMS-1