Simple Plex Human Osteopontin/OPN 2nd Gen Cartridge

Simple Plex Human Osteopontin/OPN 2nd Gen Cartridge Summary

*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.

Product Summary

Precision

Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine, Cerebrospinal Fluid

Recovery

Linearity

Product Datasheets

Preparation and Storage

Background: Osteopontin/OPN

Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell ad¬hesion, and migration. Its expression is upregulat¬ed during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.

Related Research Areas

• Adhesion Molecules in Angiogenesis
• Adhesion Molecules on VSMC
• Adipose-derived Stem Cell Markers
• Cancer Biomarkers
• Extracellular Matrix Molecules
• Gametes and Fertilization
• HIF Transcription Factors
• Integrins and Associated Molecules
• Molecules Secreted by VSMC
• Osteoblast Markers
• Osteogenesis Markers
• Renal Markers