Simple Plex Mouse IFN-gamma Cartridge

Simple Plex Mouse IFN-gamma Cartridge Summary

*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.

Product Summary

Recovery

Linearity

Product Datasheets

Preparation and Storage

Background: IFN-gamma

IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits.

Related Research Areas

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• Inflammatory Mediators
• Interferons
• Isolation, Culture, and Identification of Natural Killer Cells
• Macrophage Activation Markers
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• Molecules Secreted by VSMC
• Multiple Sclerosis and Myelin Related Molecules
• Myeloid-derived Suppressor Cells (MDSC)
• Natural Killer T (NKT) Cells
• NCR+ILC3
• NCR-ILC3
• Neuroinflammatory Factors
• Regulatory T Cells (Tregs)
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• T Cell Cytokine Signaling
• Th1 Cells