Home / Dopamine D4 Receptor Antagonists / Sonepiprazole

Sonepiprazole

Catalog #: 4185
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4185/10
4185/50
Sonepiprazole | CAS No. 170858-33-0 | Dopamine D4 Receptor Antagonists
1 Image
Description: Selective D4 antagonist
Alternative Names: PNU 101387,U 101387

Chemical Name: 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

Sonepiprazole is a selective, high affinity antagonist for the rat and human dopamine D4 receptor (Ki = 10 nM). Exhibits low affinity at other monoamine receptors (Ki > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine (Cat. No. 0444). Brain penetrant and orally available.

Technical Data

M.Wt:
401.52
Formula:
C21H27N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
170858-33-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Sonepiprazole

The citations listed below are publications that use Tocris products. Selected citations for Sonepiprazole include:

1 Citation: Showing 1 - 1

  1. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
    Authors: Nagata Et al.
    Sci Rep  2019;9:16438

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Sonepiprazole

There are currently no reviews for this product. Be the first to review Sonepiprazole and earn rewards!

Have you used Sonepiprazole?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.