Home / Ubiquitin Ligase (E3) Inhibitors / SP 141

SP 141

Catalog #: 5332
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5332/10
5332/50
SP 141 | CAS No. 1253491-42-7 | Ubiquitin Ligase (E3) Inhibitors
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Description: High affinity MDM2 inhibitor

Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.

Technical Data

M.Wt:
324.38
Formula:
C22H16N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1253491-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SP 141

The citations listed below are publications that use Tocris products. Selected citations for SP 141 include:

2 Citations: Showing 1 - 2

  1. MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma.
    Authors: Weiming Et al.
    Pathol Oncol Res  2023;29:1610801
  2. MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53.
    Authors: Carol Et al.
    Proc Natl Acad Sci U S A  2021;118

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