Home / Pregnane X Receptor Agonists / SR 12813

SR 12813

Catalog #: 2969
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2969/10
2969/50
SR 12813 | CAS No. 126411-39-0 | Pregnane X Receptor Agonists
1 Image
Description: Pregnane X receptor agonist

Chemical Name: [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SR 12813 is a pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolemic activity via enhanced degradation of HMG-CoA reductase.

Technical Data

M.Wt:
504.53
Formula:
C24H42O7P2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
126411-39-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Berkhout et al.
    J.Biol.Chem., 1996;271:14376
  2. Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.
    Lemaire et al.
    Mol.Pharmacol., 2007;72:572
  3. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
    Jones et al.
    Mol.Pharmacol., 2000;14:27

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for SR 12813

The citations listed below are publications that use Tocris products. Selected citations for SR 12813 include:

1 Citation: Showing 1 - 1

  1. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.
    Authors: Delfosse Et al.
    Nat Commun  2015;6:8089

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SR 12813

There are currently no reviews for this product. Be the first to review SR 12813 and earn rewards!

Have you used SR 12813?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.