Home / CCK1 Receptor Antagonists / SR 27897

SR 27897

Catalog #: 2190
1 Citation Datasheet / COA / SDS
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2190/50
SR 27897 | CAS No. 136381-85-6 | CCK1 Receptor Antagonists
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Description: Potent and selective CCK1 antagonist
Alternative Names: Lintitript

Chemical Name: 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

SR 27897 is a potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.

Technical Data

M.Wt:
411.86
Formula:
C20H14ClN3O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
136381-85-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding.
    Gouldson et al.
    Eur.J.Pharmacol., 1999;383:339
  2. Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors.
    Cano et al.
    Br.J.Pharmacol., 2003;140:647
  3. Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors.
    Gully et al.
    Eur.J.Pharmacol., 1993;23:232

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Citation for SR 27897

The citations listed below are publications that use Tocris products. Selected citations for SR 27897 include:

1 Citation: Showing 1 - 1

  1. Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.
    Authors: Wu Et al.
    Toxicol Sci  2014;138:278

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