SR 3576

Catalog #: 5044 Datasheet / COA / SDS

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SR 3576 | CAS No. 1164153-22-3 | JNK/c-jun Inhibitors

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Description: Highly potent and selective JNK3 inhibitor

Chemical Name: 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide

Purity: ≥97%

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Biological Activity

SR 3576 is a highly potent and selective JNK3 inhibitor (IC₅₀ = 7 nM); exhibits > 2800-fold selectivity over p38.

Technical Data

M.Wt:

501.53

Formula:

C₂₇H₂₇N₅O₅

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥97%

Storage:

Store at -20°C

CAS No:

1164153-22-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38.
Kamenecka et al.
J Biol Chem., 2009;284:12853

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