SSR 69071
Chemical Name: 2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one
Purity: ≥98%
Biological Activity
SSR 69071 is a high affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury.
Bidouard et al.
Eur.J.Pharmacol., 2003;461:49 -
A novel orally active inhibitor of HLE.
Varga et al.
Eur.J.Med.Chem., 2003;38:421 -
Biochemical and pharmacological characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-α]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active ela
Kapui et al.
J.Pharmacol.Exp.Ther., 2003;305:451
Product Datasheets
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Citations for SSR 69071
The citations listed below are publications that use Tocris products. Selected citations for SSR 69071 include:
3 Citations: Showing 1 - 3
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Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase.
Authors: Li Et al.
PLoS One 2013;8:e72563
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Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation.
Authors: Reardon Et al.
Immunity 2011;35:223
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Pivotal role for alpha1-antichymotrypsin in skin repair.
Authors: Hoffmann Et al.
J Biol Chem 2011;286:28889
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