STOCK2S 26016
Chemical Name: 7-Ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine
Purity: ≥98%
Biological Activity
STOCK2S 26016 is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.
Mori et al.
Biochem.J., 2013;455:339
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