Home / CRF1 Receptor Agonists / Stressin I

Stressin I

Catalog #: 1608
2 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1608/500U
Stressin I
1 Image
Description: CRF1 agonist
Alternative Names: cyclo(31-34)[D-Phe12,Nle21,38,Glu31,Lys34]Ac-hCRF (4-41)

Purity: ≥95%

Product Details
Citations (2)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

Technical Data

M.Wt:
4472.24
Formula:
C203H337N57O56
Sequence:
PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII

(Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the SALK Institute

Background References

  1. CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior.
    Bruchas et al.
    PLoS One., 2009;4:e8528
  2. Stressin1-A, a potent cortico. releasing factor receptor 1 (CRF1)-selective peptide agonist.
    Rivier et al.
    J.Med.Chem., 2007;50:1668
  3. Receptor-selective cortico. releasing factor analogs.
    Rivier et al.
    Endocrin.Soc.Abstr., 2002;:P2-50

Product Datasheets

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Citations for Stressin I

The citations listed below are publications that use Tocris products. Selected citations for Stressin I include:

2 Citations: Showing 1 - 2

  1. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
    Authors: Silberman and Winder
    Neuropharmacology  2013;70:316
  2. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
    Authors: Land Et al.
    J Neurosci  2008;28:407

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Stressin 1 modulation of GABA transmission
By Anonymous on 05/10/2018

Exogenous application of various concentrations onto acute brain slices was used to examine CRF1 receptor modulation of GABA transmission in the central amygdala.

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