Sulfidefluor 7 AM
Chemical Name: N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[(3',6'-diazido-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]glycine (acetyloxy)methyl ester
Biological Activity
Sulfidefluor 7 AM is a reported to be a hydrogen sulphide (H2S) fluorescent probe. Contains an acetoxymethyl ester, which enhances cell permeability and is hydrolyzed inside the cell to trap the probe. Used to visualize VEGF-induced H2S production in human umbilical vein endothelial cells (HUVECS). Excitation wavelength ~ 495 nm; emission maximum ~ 520 nm.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production.
Lin et al.
Proc.Natl.Acad.Sci.USA., 2013;110:7131 -
Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.
Lippert et al.
J.Am.Chem.Soc., 2011;133:10078
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Citations for Sulfidefluor 7 AM
The citations listed below are publications that use Tocris products. Selected citations for Sulfidefluor 7 AM include:
4 Citations: Showing 1 - 4
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Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage.
Authors: Xiaofeng Et al.
Cell Chem Biol 2021;28:1669-1678.e5
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Periprocedural Hydrogen Sulfide Therapy Improves Vascular Remodeling and Attenuates Vein Graft Disease.
Authors: Margreet R Et al.
J Am Heart Assoc 2020;9:e016391
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Glucose-6-phosphate dehydrogenase is critical for suppression of cardiac hypertrophy by H2S.
Authors: Chhabra Et al.
Cell Death Discov 2018;4:6
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Restoration of Hydrogen Sulfide Production in Diabetic Mice Improves Reparative Function of Bone Marrow Cells.
Authors: Cheng Et al.
Circulation 2016;134:1467
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