T2AA
Chemical Name: (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
Purity: ≥98%
Biological Activity
T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
Punchihewa C, Inoue A, Hishiki A et al.
J Biol Chem
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Citation for T2AA
The citations listed below are publications that use Tocris products. Selected citations for T2AA include:
1 Citation: Showing 1 - 1
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Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo.
Authors: Carl L Et al.
Cell Rep 2020;30:1329-1341.e5
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