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T4

Catalog #: 7054 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7054/10
7054/50
T4 | CAS No. 785708-33-0 | DNA, RNA and Protein Synthesis Compounds
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Description: Modulator of alternative polyadenylation; inhibits rod photoreceptor gene expression via Nr2e3

Chemical Name: 6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl)]quinazolin-4(3H)-one

Purity: ≥98%

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Biological Activity

T4 is a modulator of alternative polyadenylation (APA) (IC50 values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively). T4 promotes distal-to-proximal APA usage in multiple transcripts, using distinctive A-rich motifs through autoregulated PABPN1 signaling. T4 exhibits no inhibitory activity against a panel of 414 kinases. T4 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. T4 inhibits rod photoreceptor gene expression via Nr2e3 in a luciferase-based assay (IC50 = 0.07 μM).

Technical Data

M.Wt:
377.44
Formula:
C22H23N3O3
Solubility:
Soluble to 2 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
785708-33-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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