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TACS-XL In Situ Apoptosis Detection Kit - TACS Blue

Catalog #: 4828-30-BK
21 Citations Datasheet / COA / SDS
TUNEL-based Apoptosis Detection Assay
Catalog # Availability Size / Price Qty
4828-30-BK
Mouse Lung Parenchyma Tissue_TACS XL In Situ Apoptosis Kit
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TACS-XL In Situ Apoptosis Detection Kit - TACS Blue Summary

Assay Principle

TUNEL Assay Principle - TACS XL
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The TACS-XL® In Situ Apoptosis Detection Kit - Blue Label is a TUNEL assay designed for fixed cells, embedded tissue, and frozen tissue using light and electron microscopy. This kit utilizes a novel approach for the detection of apoptosis that is based on incorporation of bromodeoxyuridine (BrdU) at the 3’ OH ends of the DNA fragments that form during apoptosis. This detection system uses a biotin conjugated anti-BrdU antibody and streptavidin-horseradish peroxidase.

This kit contains dNTP Mix, TdT Enzyme, TACS Blue Label®, Streptavidin-HRP, Nuclear Fast Red counterstain, buffers, and other reagents necessary for generating positive controls.

Label: BrdU/Conjugated BrdU Antibody/Streptavidin-HRP/TACS Blue Label
Testing Format: Light Microscopy, Electron Microscopy
Sample Type: Fixed cells, Embedded tissues, Frozen tissues
Size: 30 Tests

DNA Fragmentation in Mouse Lung Parenchyma Tissue Detected using the TACS XL® Blue Kit

Mouse lung parenchyma tissue was fixed and embedded in paraffin. Five micron sections were prepared and immobilized on slides. The tissue was labeled as describe in the TACS XL protocol (Catalog # 4828-30-BK) and analyzed by light microscopy for DNA fragmentation indicated by the blue stained cells. Data was provided courtesy of F. D'Agostini, University of Genova Via A. Pastore, Genova, Italy.

TACS XL is a registered trademark of Trevigen, Inc.

Specifications

Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
The product requires storage at -20 to -70 °C, 2 - 8 °C, and room temperature.  Consult the product insert for specific storage temperatures. Do not use past expiration date.

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Scientific Data

N/A Mouse Lung Parenchyma Tissue_TACS XL In Situ Apoptosis Kit View Larger

DNA Fragmentation in Mouse Lung Parenchyma Tissue Detected using the TACS XL® Blue Kit. Mouse lung parenchyma tissue was fixed and embedded in paraffin. Five micron sections were prepared and immobilized on slides. The tissue was labeled as describe in the TACS XL kit protocol (Catalog # 4828-30-BK) and analyzed by light microscopy for DNA fragmentation indicated by the blue stained cells. Data was provided courtesy of F. D'Agostini, University of Genova Via A. Pastore, Genova, Italy.

Citations for TACS-XL In Situ Apoptosis Detection Kit - TACS Blue

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

21 Citations: Showing 1 - 10
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  1. ZnT2 Is Critical for TLR4-Mediated Cytokine Expression in Colonocytes and Modulates Mucosal Inflammation in Mice
    Authors: K McGourty, R Vijayakuma, T Wu, A Gagnon, SL Kelleher
    International Journal of Molecular Sciences, 2022-09-28;23(19):.  2022-09-28
  2. Domestic cat hepadnavirus associated with hepatopathy in cats: A retrospective study
    Authors: C Piewbang, W Dankaona, P Poonsin, J Yostawonku, S Lacharoje, S Sirivisoot, T Kasantikul, P Tummaruk, S Techangams
    Journal of veterinary internal medicine, 2022-08-24;0(0):.  2022-08-24
  3. Mycobacterium avium subsp. hominissuis (MAH) Microaggregate induction of host innate immunity is linked to biofilm formation
    Authors: BF Keefe, A Leestemake, LE Bermudez
    Microbial pathogenesis, 2021-05-18;157(0):104977.  2021-05-18
  4. Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment
    Authors: J Kelschenba, H He, BH Kim, A Borjabad, CJ Gu, W Chao, M Do, LR Sharer, H Zhang, O Arancio, MJ Potash, DJ Volsky
    MBio, 2019-07-02;10(4):.  2019-07-02
  5. Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants
    Authors: A Introini, S Boström, F Bradley, A Gibbs, A Glaessgen, A Tjernlund, K Broliden
    PLoS Pathog., 2017-05-19;13(5):e1006402.  2017-05-19
  6. P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
    Authors: Lopez-Barcons L, Maurer B, Kang M, Reynolds C
    Int J Cancer, 2017-05-09;141(2):405-413.  2017-05-09
  7. Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
    Authors: Zhang Y, Cross S, Stanton J, Marmorstein A, Le Y, Marmorstein L
    Mol Vis, 2017-04-14;23(0):228-241.  2017-04-14
  8. Targeting Th17-IL-17 Pathway in Prevention of Micro-Invasive Prostate Cancer in a Mouse Model.
    Authors: Zhang Q, Liu S, Ge D, Cunningham D, Huang F, Ma L, Burris T, You Z
    Prostate, 2017-02-27;77(8):888-899.  2017-02-27
  9. The Effect of Chronic Ozone Exposure on the Activation of Endoplasmic Reticulum Stress and Apoptosis in Rat Hippocampus
    Authors: Selva Rivas-Aran
    Front Aging Neurosci, 2016-10-25;8(0):245.  2016-10-25
  10. Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition
    Oncogene, 2016-07-04;0(0):.  2016-07-04
  11. Two Distinct Isoforms of Matrix Metalloproteinase-2 Are Associated with Human Delayed Kidney Graft Function.
    Authors: Wanga S, Ceron C, Delgado C, Joshi S, Spaulding K, Walker J, Song S, Olson J, Lovett D
    PLoS ONE, 2015-09-17;10(9):e0136276.  2015-09-17
  12. Antiaging Gene Klotho Attenuates Pancreatic beta-Cell Apoptosis in Type 1 Diabetes.
    Authors: Lin Y, Sun Z
    Diabetes, 2015-09-04;64(12):4298-311.  2015-09-04
  13. A lysigenic programmed cell death-dependent process shapes schizogenously formed aerenchyma in the stems of the waterweed Egeria densa.
    Authors: Bartoli G, Forino L, Durante M, Tagliasacchi A
    Ann Bot, 2015-05-22;116(1):91-9.  2015-05-22
  14. Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation.
    Authors: Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G
    J Biol Chem, 2014-10-22;289(51):35246-63.  2014-10-22
  15. Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism.
    Authors: Lee H, Seo U, Kim W, Woo S, Lee J
    J Int Med Res, 2013-01-28;41(1):97-105.  2013-01-28
  16. Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.
    Authors: Park J, Sarode V, Euhus D, Kittler R, Scherer P
    Proc Natl Acad Sci U S A, 2012-12-03;109(51):21058-63.  2012-12-03
  17. PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.
    Authors: Yamato, Ichiro, Sho, Masayuki, Shimada, Keiji, Hotta, Kiyohiko, Ueda, Yuko, Yasuda, Satoshi, Shigi, Naoko, Konishi, Noboru, Tsujikawa, Kazutake, Nakajima, Yoshiyuk
    Cancer Res, 2012-07-23;72(18):4829-39.  2012-07-23
  18. Interleukin-17 promotes formation and growth of prostate adenocarcinoma in mouse models.
    Authors: Zhang Q, Liu S, Ge D, Zhang Q, Xue Y, Xiong Z, Abdel-Mageed A, Myers L, Hill S, Rowan B, Sartor O, Melamed J, Chen Z, You Z
    Cancer Res, 2012-03-28;72(10):2589-99.  2012-03-28
  19. Ventricular preexcitation modulates strain and attenuates cardiac remodeling in a swine model of myocardial infarction.
    Authors: Shuros AC, Salo RW, Florea VG, Pastore J, Kuskowski MA, Chandrashekhar Y, Anand IS
    Circulation, 2007-08-20;116(10):1162-9.  2007-08-20
  20. Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.
    Authors: Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA
    Virus Res., 2004-11-01;106(1):35-42.  2004-11-01
  21. Polyethylene glycol reduces the inflammatory injury due to cold ischemia/reperfusion in autotransplanted pig kidneys.
    Authors: Hauet T, Goujon JM, Baumert H, Petit I, Carretier M, Eugene M, Vandewalle A
    Kidney Int., 2002-08-01;62(2):654-67.  2002-08-01

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