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Tamsulosin hydrochloride

Catalog #: 3050
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3050/10
3050/50
Tamsulosin hydrochloride | CAS No. 106463-17-6 | Adrenergic alpha-1 Receptor Antagonists
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Description: Selective α1A antagonist

Chemical Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

Tamsulosin hydrochloride is a selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligible effect on mean arterial blood pressure in vivo.

Technical Data

M.Wt:
444.97
Formula:
C20H28N2O5S.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
106463-17-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species.
    Garcia-Sainz et al.
    Eur.J.Pharmacol., 1995;289:1
  2. Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes.
    Taguchi et al.
    J.Pharmacol.Exp.Ther., 1997;280:1

Product Datasheets

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Citations for Tamsulosin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Tamsulosin hydrochloride include:

3 Citations: Showing 1 - 3

  1. Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system.
    Authors: Xiao Et al.
    Commun Biol  2019;2:33
  2. Inhibition of smooth muscle force generation by focal adhesion kinase inhibitors in the hyperplastic human prostate.
    Authors: Kunit Et al.
    Am J Physiol Renal Physiol  2014;307:F823
  3. Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways.
    Authors: Trevisani Et al.
    Br J Pharmacol  2005;145:1123

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