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TASP 0277308

Catalog #: 6498 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6498/5
TASP 0277308 | CAS No. 945725-50-8 | Sphingosine-1-phosphate Receptor Antagonists
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Description: Potent and selective S1P1 receptor antagonist; inhibits angiogenesis

Chemical Name: 3,4-Dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide

Purity: ≥98%

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Biological Activity

TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesis in vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECs in vitro and reverses or impairs the development of arthritis or mechano-allodynia.

Technical Data

M.Wt:
539.48
Formula:
C23H28Cl2N6O3S
Solubility:
Soluble to 5 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
945725-50-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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