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TAT-PDHPS1

Catalog #: 7832 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7832/1
TAT-PDHPS1
1 Image
Description: Peptide inhibitor of YAP signaling

Purity: ≥95%

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Biological Activity

TAT-PDHPS1 is a peptide inhibitor of Yes-associated protein (YAP) signaling. It comprises the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence, TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), which activates protein phosphatase 2A (PP2A). This activation leads to the phosphorylation of YAP and the suppression of YAP-targeted genes. TAT-PDHPS1 inhibits the proliferation of ovarian cancer cells in vitro and ovarian tumor growth in a subcutaneous xenograft mouse model.

Technical Data

M.Wt:
3744.32
Formula:
C156H280N62O45
Sequence:
GRKKRRQRRRPPQQIATTTASAATAAAIGATPRAK
Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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