TC-I 15

Catalog # Availability Size / Price Qty
4527/10
4527/50
TC-I 15 | CAS No. 916734-43-5 | Integrin Receptor Inhibitors
1 Image
Description: Potent α2β1 inhibitor; displays antithrombotic activity in vivo

Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

TC-I 15 is a potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.

Technical Data

M.Wt:
520.62
Formula:
C23H28N4O6S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
916734-43-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Pennsylvania.

Product Datasheets

Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for TC-I 15

The citations listed below are publications that use Tocris products. Selected citations for TC-I 15 include:

4 Citations: Showing 1 - 4

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TC-I 15

There are currently no reviews for this product. Be the first to review TC-I 15 and earn rewards!

Have you used TC-I 15?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.