TC-I 2014
Chemical Name: 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
Purity: ≥98%
Biological Activity
TC-I 2014 is a potent TRPM8 antagonist (IC50 values are 0.8, 3.0 and 4.4 nM for canine, human and rat channels respectively). Exhibits antiallodynic properties in pain models in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Parks et al.
J.Med.Chem., 2011;54:233
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Citation for TC-I 2014
The citations listed below are publications that use Tocris products. Selected citations for TC-I 2014 include:
1 Citation: Showing 1 - 1
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Structural insights into TRPM8 inhibition and desensitization.
Authors: Diver Et al.
Science 2019;365:1434
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