TC-MCH 7c
Chemical Name: 4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone
Purity: ≥97%
Biological Activity
TC-MCH 7c is a potent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists.
Haga et al.
Bioorg.Med.Chem., 2011;19:883 -
Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.
Ito et al.
Eur.J.Pharmacol., 2009;624:77
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Citations for TC-MCH 7c
The citations listed below are publications that use Tocris products. Selected citations for TC-MCH 7c include:
2 Citations: Showing 1 - 2
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Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents.
Authors: Hi-Joon Et al.
Exp Neurobiol 2020;29:453-469
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Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice.
Authors: Hi-Joon Et al.
Mol Neurobiol 2019;56:2408-2423
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