TC-S 7001
Chemical Name: 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
Purity: ≥98%
Biological Activity
TC-S 7001 (also known as BAY-549) is a potent and highly selective ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for human ROCK1 and ROCK2, respectively), which exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. TC-S 7001 reduces blood pressure in normotensive and hypertensive rats, and is orally active.External Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of TC-S 7001 (BAY 549) is reviewed on chemicalprobes.org and the SGC website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase.
Kast et al.
Br.J.Pharmacol., 2007;152:1070 -
Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.
Dahal et al.
Eur.Resp.J., 2010;36:808
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