TC-S 7004
Chemical Name: N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Purity: ≥98%
Biological Activity
TC-S 7004 is a potent and selective DYRK1A/B inhibitor (IC50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells.
Ewton et al.
Mol.Cancer Ther., 2011;10:2104 -
Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Anderson et al.
Bioorg.Med.Chem.Lett., 2013;15:6610
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Citation for TC-S 7004
The citations listed below are publications that use Tocris products. Selected citations for TC-S 7004 include:
1 Citation: Showing 1 - 1
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Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
Authors: Blake Et al.
Sci Signal 2019;12
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