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TCS JNK 6o

Catalog #: 3222
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3222/10
3222/50
TCS JNK 6o | CAS No. 894804-07-0 | JNK/c-jun Inhibitors
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Description: Selective JNK inhibitor

Chemical Name: N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.

TCS JNK 6o synthesized to Ancillary Material Grade also available.

Technical Data

M.Wt:
356.38
Formula:
C18H20N4O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
894804-07-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TCS JNK 6o

The citations listed below are publications that use Tocris products. Selected citations for TCS JNK 6o include:

3 Citations: Showing 1 - 3

  1. Targeting JNK pathway promotes human hematopoietic stem cell expansion.
    Authors: Xiao Et al.
    Cell Discov  2019;5:2
  2. Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection.
    Authors: Souvannaseng Et al.
    PLoS Pathog  2018;14:e1007418
  3. Establishment of mouse expanded potential stem cells.
    Authors: Yang Et al.
    Nature  2017;550:393

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