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Terazosin hydrochloride

Catalog #: 1506
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1506/50
Terazosin hydrochloride | CAS No. 63074-08-8 | Adrenergic alpha-1 Receptor Antagonists
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Description: α1 and α2B antagonist (α1 > α2B). Orally active

Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

Terazosin hydrochloride is a α1- and α2B-adrenoceptor antagonist (Ki values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo.

Technical Data

M.Wt:
423.9
Formula:
C19H25N5O4.HCl
Solubility:
Soluble to 50 mM in water with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
63074-08-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacology of tera.
    Kyncl
    Am.J.Med., 1986;80:12
  2. Actions of tera. and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro.
    Hancock et al.
    J.Recept.Signal Transduct.Res., 1995;15:863
  3. Comparison of displacemental potencies of tera. enantiomers for α1-adrenoceptor subtypes.
    Maruyama et al.
    Biol.Pharm.Bull., 1994;17:1126

Product Datasheets

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Citations for Terazosin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Terazosin hydrochloride include:

2 Citations: Showing 1 - 2

  1. The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
    Authors: Kahn Et al.
    EMBO Mol Med  2016;8:511
  2. Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
    Authors: Bucher Et al.
    J Cereb Blood Flow Metab  2014;34:1128

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