TFM-4AS-1
Chemical Name: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-6,9a,11a-Trimethyl-7-oxo-N-[2-(trifluoromethyl)phenyl]-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide
Purity: ≥98%
Biological Activity
TFM-4AS-1 is a potent selective androgen receptor modulator (SARM) (IC50 = 30 nM). Steroidal compound. Exhibits limited effects on reproductive tissues and sebaceous glands; does not repress AP-1-sensitive MMP-1 reporter. Inhibits 5α-reductase type I and II (IC50 values are 2 and 3 nM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands.
Schmidt et al.
J.Biol.Chem., 2009;284:36367
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Citation for TFM-4AS-1
The citations listed below are publications that use Tocris products. Selected citations for TFM-4AS-1 include:
1 Citation: Showing 1 - 1
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Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition.
Authors: Jennifer J Et al.
Toxicol Sci 2020;177:466-475
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