Tiotidine
Purity: ≥99%
Biological Activity
Tiotidine is a potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Distribution, properties, and functional characteristics of three classes of histamine receptor.
Hill et al.
Pharmacol.Rev., 1990;42:45 -
The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist.
Trzeciakowski and Levi
J.Pharmacol.Exp.Ther., 1980;214:629 -
ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors.
Yellin et al.
Life Sci., 1979;25:2001
Product Datasheets
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Citations for Tiotidine
The citations listed below are publications that use Tocris products. Selected citations for Tiotidine include:
5 Citations: Showing 1 - 5
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Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
Authors: Nagata Et al.
Sci Rep 2019;9:16438
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Physiological implications of biased signaling at histamine H2 receptors.
Authors: Alonso Et al.
Exp Ther Med 2015;6:45
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Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.
Authors: Chigaev Et al.
J Biol Chem 2011;286:20375
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Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
Authors: Holden Et al.
Front Pharmacol 2007;152:891
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Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
Authors: Flamand Et al.
Br J Pharmacol 2004;141:552
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