TNP
Chemical Name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
Purity: ≥97%
Biological Activity
TNP is a reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates.
Padmanabhan et al.
J.Biol.Chem., 2009;284:10571 -
Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase.
Chang et al.
Chembiochem, 2002;3:897
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Citation for TNP
The citations listed below are publications that use Tocris products. Selected citations for TNP include:
1 Citation: Showing 1 - 1
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Acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals.
Authors: Andrew M Et al.
Acta Physiol (Oxf) 2022;235:e13815
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